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Invitrogen
PKC beta-2 Monoclonal Antibody (8/1)
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Product Details
13-3700
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
8/1
Immunogen
Purified rat brain PKC.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533014
Target Information
The PKC family of serine/threonine kinases, including PRKCB2 (PKC beta II), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: PKC-B; PKC-beta; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide
Gene Aliases: PKC-beta; PKCB; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P05771, (Rat) P68403
Entrez Gene ID: (Human) 5579, (Rat) 25023
chromatin binding
protein serine/threonine kinase activity
protein kinase C activity
calcium-dependent protein kinase C activity
protein kinase C binding
calcium channel regulator activity
protein binding
ATP binding
zinc ion binding
ligand-dependent nuclear receptor transcription coactivator activity
histone kinase activity (H3-T6 specific)
histone binding
androgen receptor binding
response to hypoxia
adaptive immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
calcium ion transport
cellular calcium ion homeostasis
apoptotic process
mitotic nuclear envelope disassembly
signal transduction
negative regulation of glucose transport
peptidyl-serine phosphorylation
platelet activation
positive regulation of vascular endothelial growth factor receptor signaling pathway
histone H3-T6 phosphorylation
intracellular signal transduction
B cell activation
lipoprotein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
negative regulation of insulin receptor signaling pathway
B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
positive regulation of NF-kappaB transcription factor activity
cellular response to carbohydrate stimulus
response to glucose
regulation of dopamine secretion
dibenzo-p-dioxin metabolic process
response to vitamin D
regulation of growth
positive regulation of odontogenesis of dentin-containing tooth
response to drug
response to ethanol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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