Invitrogen

PKC mu Polyclonal Antibody

View all (32) PKC mu antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-116664

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 800-900 of human PKC mu (NP_0027332)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.83 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2901295

Product Specific Information

Positive Samples: SKOV3, A-549

Immunogen sequence: YPPNPWKEIS HEAIDLINNL LQVKMRKRYS VDKTLSHPWL QDYQTWLDLR ELECKIGERY ITHESDDLRW EKYAGEQGLQ YPTHLINPSA SHSDTPETEE T

Target Information

The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3

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Gene Aliases: 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D2; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3

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UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Mouse) Q8BZ03, (Mouse) Q8K1Y2

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Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Mouse) 101540, (Mouse) 75292

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Function(s)
protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding kinase activity identical protein binding metal ion binding protein kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
protein phosphorylation protein kinase C-activating G-protein coupled receptor signaling pathway intracellular signal transduction angiogenesis positive regulation of endothelial cell proliferation adaptive immune response cell adhesion cell death positive regulation of endothelial cell migration peptidyl-serine phosphorylation positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of interleukin-2 production positive regulation of interleukin-8 production positive regulation of CREB transcription factor activity positive regulation of peptidyl-serine phosphorylation cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway positive regulation of blood vessel endothelial cell migration positive regulation of fibroblast growth factor receptor signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation vascular endothelial growth factor receptor signaling pathway T cell receptor signaling pathway positive regulation of T cell receptor signaling pathway positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity endothelial tube morphogenesis positive regulation of ERK1 and ERK2 cascade protein kinase D signaling mitophagy in response to mitochondrial depolarization positive regulation of histone deacetylase activity positive regulation of intracellular signal transduction positive regulation of DNA biosynthetic process positive regulation of endothelial cell chemotaxis phosphorylation immune system process apoptotic process inflammatory response Golgi organization nervous system development regulation of keratinocyte proliferation positive regulation of neuron projection development cell differentiation cellular response to oxidative stress positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of osteoblast differentiation Golgi vesicle transport regulation of release of sequestered calcium ion into cytosol negative regulation of cell death signal transduction integrin-mediated signaling pathway Ras protein signal transduction cell proliferation sphingolipid biosynthetic process regulation of protein stability negative regulation of endocytosis regulation of integrin-mediated signaling pathway
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