Invitrogen

PKC zeta Monoclonal Antibody (S.228.2)

View all (25) PKC zeta antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-14995

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

S.228.2

Immunogen

Synthetic peptide corresponding to human PKC zeta.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10988550

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with other PKC isoforms.

Target Information

The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 14 - 3 - 3 - zeta isoform; atypical protein kinase C; kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, zeta

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Gene Aliases: 14-3-3-zetaisoform; AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-ZETA; PKC2; Pkcz; PRKCZ; r14-3-3; R74924; zetaPKC

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UniProt ID: (Human) Q05513, (Rat) P09217, (Mouse) Q02956

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Entrez Gene ID: (Human) 5590, (Rat) 25522, (Mouse) 18762

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding potassium channel regulator activity protein kinase binding protein domain specific binding phospholipase binding insulin receptor substrate binding metal ion binding 14-3-3 protein binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
microtubule cytoskeleton organization positive regulation of cell-matrix adhesion protein phosphorylation inflammatory response signal transduction cell surface receptor signaling pathway long-term memory positive regulation of cell proliferation insulin receptor signaling pathway cell migration peptidyl-serine phosphorylation establishment of cell polarity negative regulation of protein complex assembly actin cytoskeleton reorganization activation of phospholipase D activity activation of protein kinase B activity positive regulation of interleukin-4 production cellular response to insulin stimulus cellular protein localization intracellular signal transduction negative regulation of apoptotic process positive regulation of T-helper 2 cell differentiation positive regulation of glucose import negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway vesicle transport along microtubule negative regulation of peptidyl-tyrosine phosphorylation positive regulation of synaptic transmission positive regulation of NF-kappaB transcription factor activity positive regulation of protein transport protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization long-term synaptic potentiation positive regulation of ERK1 and ERK2 cascade protein kinase C signaling protein localization to plasma membrane neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion transforming growth factor beta receptor signaling pathway phosphorylation
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