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Osenses
PKD1 Polyclonal Antibody
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Product Details
OSP00005W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from human PKD1 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: PKD1.
Target Information
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Autosomal dominant polycystic kidney disease 1 protein; PC1; polycystic kidney disease 1 (autosomal dominant); polycystic kidney disease-associated protein; polycystin 1; Polycystin-1; transient receptor potential cation channel, subfamily P, member 1
Gene Aliases: PBP; Pc-1; PKD1; TRPP1
UniProt ID: (Human) P98161
Entrez Gene ID: (Human) 5310
cartilage condensation
in utero embryonic development
kidney development
liver development
embryonic placenta development
protein export from nucleus
nitrogen compound metabolic process
cell cycle arrest
homophilic cell adhesion via plasma membrane adhesion molecules
cell-matrix adhesion
calcium-independent cell-matrix adhesion
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
heart development
anatomical structure morphogenesis
single organismal cell-cell adhesion
peptidyl-serine phosphorylation
spinal cord development
neural tube development
establishment of cell polarity
regulation of cell adhesion
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
positive regulation of protein binding
response to fluid shear stress
lymph vessel morphogenesis
cytoplasmic sequestering of transcription factor
skin development
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
branching morphogenesis of an epithelial tube
genitalia development
detection of mechanical stimulus
cartilage development
regulation of mitotic spindle organization
lung epithelium development
placenta blood vessel development
regulation of proteasomal protein catabolic process
calcium ion transmembrane transport
mesonephric tubule development
mesonephric duct development
metanephric collecting duct development
metanephric ascending thin limb development
metanephric proximal tubule development
metanephric distal tubule morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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