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Product Details
PA5-29834
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Intracellular domain of human Polycystin 2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547308
Product Specific Information
Recommended positive controls: U87-MG.
Predicted reactivity: Mouse (92%), Rat (94%), Zebrafish (86%), Pig (98%), Chicken (92%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A MGC138466; Autosomal dominant polycystic kidney disease type II protein; calcium ion channel; Cup; Curly up; MGC138468; PC2; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; Polycystic kidney disease 2 protein homolog; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; transient receptor potential cation channel, subfamily P, member 2; TRPP1; TRPP2
Gene Aliases: APKD2; Pc-2; PC2; PKD2; PKD4; TRPP1; TRPP2
UniProt ID: (Human) Q13563, (Zebrafish) Q6IVV8
Entrez Gene ID: (Human) 5311, (Zebrafish) 432387
receptor binding
voltage-gated ion channel activity
voltage-gated calcium channel activity
voltage-gated sodium channel activity
potassium channel activity
calcium ion binding
protein binding
cytoskeletal protein binding
voltage-gated cation channel activity
identical protein binding
protein homodimerization activity
actinin binding
HLH domain binding
ion channel binding
calcium-induced calcium release activity
ATPase binding
phosphoprotein binding
muscle alpha-actinin binding
cation channel activity
calcium channel activity
outward rectifier potassium channel activity
metal ion binding
kidney development
lymphangiogenesis
heart looping
embryonic heart tube morphogenesis
heart jogging
atrioventricular valve development
ion transport
potassium ion transport
calcium ion transport
determination of left/right symmetry
heart development
dorsal/ventral pattern formation
regulation of cardiac muscle contraction by calcium ion signaling
Wnt signaling pathway
regulation of collagen biosynthetic process
regulation of ion transmembrane transport
pronephros development
detection of mechanical stimulus
protein tetramerization
positive regulation of sequestering of calcium ion
protein heterotetramerization
determination of heart left/right asymmetry
Kupffer's vesicle development
calcium ion transmembrane transport
cellular response to calcium ion
potassium ion transmembrane transport
proximal convoluted tubule development
pronephros morphogenesis
cellular response to oscillatory fluid shear stress
inorganic cation transmembrane transport
cell-cell signaling by wnt
branching involved in ureteric bud morphogenesis
liver development
embryonic placenta development
detection of nodal flow
cell cycle arrest
JAK-STAT cascade
negative regulation of cell proliferation
spinal cord development
neural tube development
regulation of cAMP metabolic process
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
cellular response to reactive oxygen species
metanephric part of ureteric bud development
sodium ion transmembrane transport
aorta development
regulation of cell proliferation
cytoplasmic sequestering of transcription factor
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
release of sequestered calcium ion into cytosol
centrosome duplication
regulation of postsynaptic membrane potential
negative regulation of ryanodine-sensitive calcium-release channel activity
placenta blood vessel development
renal tubule morphogenesis
renal artery morphogenesis
positive regulation of cell cycle arrest
cellular response to hydrostatic pressure
cellular response to osmotic stress
cellular response to fluid shear stress
determination of liver left/right asymmetry
metanephric mesenchyme development
mesonephric tubule development
mesonephric duct development
metanephric smooth muscle tissue development
metanephric cortex development
metanephric ascending thin limb development
metanephric cortical collecting duct development
metanephric distal tubule development
metanephric S-shaped body morphogenesis
regulation of calcium ion import
negative regulation of G1/S transition of mitotic cell cycle
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