Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
PKLR Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
17580-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PKLR Fusion Protein Ag11096 (223-574 aa encoded by BC025737)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LISLVVQKI GPEGLVTQVE NGGVLGSRKG VNLPGAQVDL PGLSEQDVRD LRFGVEHGVD IVFASFVRKA SDVAAVRAAL GPEGHGIKII SKIENHEGVK RFDEILEVSD GIMVARGDLG IEIPAEKVFL AQKMMIGRCN LAGKPVVCAT QMLESMITKP RPTRAETSDV ANAVLDGADC IMLSGETAKG NFPVEAVKMQ HAIAREAEAA VYHRQLFEEL RRAAPLSRDP TEVTAIGAVE AAFKCCAAAI IVLTTTGRSA QLLSRYRPRA AVIAVTRSAQ AARQVHLCRG VFPLLYREPP EAIWADDVDR RVQFGIESGK LRGFLRVGDL VIVVTGWRPG SGYTNIMRVL SIS (223-574 aa encoded by BC025737)
Target Information
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: isozymes R/L; L-PK; Pyruvate kinase 1; pyruvate kinase isozyme R/L; Pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; Pyruvate kinase PKLR; pyruvate kinase type L; pyruvate kinase, liver and blood cell; pyruvate kinase, liver and red blood cell; R-type/L-type pyruvate kinase; Red cell/liver pyruvate kinase
Gene Aliases: Pk-1; PK1; PKL; Pklg; PKLR; PKR; PKRL; R-PK; RPK
UniProt ID: (Human) P30613, (Rat) P12928
Entrez Gene ID: (Human) 5313, (Mouse) 18770, (Rat) 24651
carbohydrate metabolic process
glycolytic process
ATP biosynthetic process
metabolic process
response to heat
response to lithium ion
phosphorylation
cellular response to insulin stimulus
response to ATP
pyruvate biosynthetic process
response to cAMP
response to other organism
response to hypoxia
response to nutrient
response to glucose
canonical glycolysis
response to metal ion
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support