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Proteintech
PKM Polyclonal Antibody
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Product Details
25659-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PKM Fusion Protein Ag20270 (1-531 aa encoded by BC000481)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize both PK-M1 and PK-M2.
Immunogen sequence: MSKPHSEAG TAFIQTQQLH AAMADTFLEH MCRLDIDSPP ITARNTGIIC TIGPASRSVE TLKEMIKSGM NVARLNFSHG THEYHAETIK NVRTATESFA SDPILYRPVA VALDTKGPEI RTGLIKGSGT AEVELKKGAT LKITLDNAYM EKCDENILWL DYKNICKVVE VGSKIYVDDG LISLQVKQKG ADFLVTEVEN GGSLGSKKGV NLPGAAVDLP AVSEKDIQDL KFGVEQDVDM VFASFIRKAS DVHEVRKVLG EKGKNIKIIS KIENHEGVRR FDEILEASDG IMVARGDLGI EIPAEKVFLA QKMMIGRCNR AGKPVICATQ MLESMIKKPR PTRAEGSDVA NAVLDGADCI MLSGETAKGD YPLEAVRMQH LIAREAEAAI YHLQLFEELR RLAPITSDPT EATAVGAVEA SFKCCSGAII VLTKSGRSAH QVARYRPRAP IIAVTRNPQT ARQAHLYRGI FPVLCKDPVQ EAWAEDVDLR VNFAMNVGKA RGFFKKGDVV IVLTGWRPGS GFTNTMRVVP VP (1-531 aa encoded by BC000481)
Target Information
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CTHBP; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; m2pk; OIP-3; OPA-interacting protein 3; p58; PK, muscle type; Pyruvate kinase 2/3; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; Pyruvate kinase PKM; THBP1; Threonine-protein kinase PKM2; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; Tumor M2-PK; Tyrosine-protein kinase PKM2
Gene Aliases: CTHBP; HEL-S-30; OIP3; PK2; PK3; PKM; PKM2; TCB; THBP1
UniProt ID: (Human) P14618
Entrez Gene ID: (Human) 5315
response to hypoxia
liver development
ATP biosynthetic process
response to nutrient
response to gravity
programmed cell death
response to muscle inactivity
organ regeneration
response to insulin
pyruvate biosynthetic process
skeletal muscle tissue regeneration
canonical glycolysis
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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