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Invitrogen
PLA2 Polyclonal Antibody
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PLA2 Antibody (PA5-96336) in IHC (P)
Immunohistochemistry analysis of PLA2 in paraffin-embedded mouse pancreas. Samples were incubated with PLA2 Polyclonal antibody (Product # PA5-96336) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96336
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 23-148 of human PLA2G1B (NP_0009191)
Conjugate
Form
Liquid
Concentration
1.67 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808138
Product Specific Information
Immunogen sequence: AVWQFRKMIK CVIPGSDPFL EYNNYGCYCG LGGSGTPVDE LDKCCQTHDN CYDQAKKLDS CKFLLDNPYT HTYSYSCSGS AITCSSKNKE CEAFICNCDR NAAICFSKAP YNKAHKNLDT KKYCQS; Positive Samples: A-549, Mouse pancreas, Mouse small intestine
Target Information
Phospholipase A2 catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Group IB phospholipase A2; MGC119834; MGC119835; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2, group IB (pancreas); PLA2-Ib
Gene Aliases: PLA2; PLA2A; PLA2G1B; PPLA2; sPLA2IB
UniProt ID: (Human) P04054, (Mouse) Q9Z0Y2
Entrez Gene ID: (Human) 5319, (Mouse) 18778
innate immune response in mucosa
lipid metabolic process
fatty acid biosynthetic process
phospholipid metabolic process
phospholipid catabolic process
lipid catabolic process
antibacterial humoral response
multicellular organism lipid catabolic process
positive regulation of DNA replication
phosphatidylcholine metabolic process
defense response to Gram-positive bacterium
activation of MAPK activity
neutrophil mediated immunity
phosphatidic acid biosynthetic process
actin filament organization
signal transduction
positive regulation of calcium ion transport into cytosol
glucose transport
leukotriene biosynthetic process
neutrophil chemotaxis
activation of phospholipase A2 activity
interleukin-8 production
cellular response to insulin stimulus
intracellular signal transduction
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fibroblast proliferation
arachidonic acid secretion
positive regulation of protein secretion
positive regulation of immune response
positive regulation of NF-kappaB transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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