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Invitrogen
PLA2G2A Polyclonal Antibody
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Product Details
PA5-76118
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human PLA2G2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2719845
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.1.1.4; EF; Enhancing factor; GIIC sPLA2; Group IIA phospholipase A2; modifier of Min1; non-pancreatic secreted type II phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); Phospholipase A2, membrane associated; PLA2BPLA2; PLA2LPLA2S; secretory group II phospholipase A2
Gene Aliases: EF; MOM1; PLA2; PLA2B; PLA2G2A; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2; sPla2-IIA
UniProt ID: (Human) P14555, (Mouse) P31482
Entrez Gene ID: (Human) 5320, (Mouse) 18780
phospholipid metabolic process
phosphatidic acid biosynthetic process
positive regulation of macrophage derived foam cell differentiation
lipid catabolic process
low-density lipoprotein particle remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidic acid metabolic process
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
lipid metabolic process
negative regulation of cell proliferation
somatic stem cell population maintenance
regulation of growth
regulation of cell proliferation
negative regulation of T cell proliferation
regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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