Proteintech

PLA2G4E Polyclonal Antibody

PLA2G4E Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 11

PLA2G4E Antibody (18088-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle using 18088-1-AP (PLA2G4E antibody) at dilution of 1:50 (under 40x lens).

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Product Details

18088-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PLA2G4E Fusion Protein Ag12808 (507-856 aa encoded by BC101584)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KDDVSNQDF REWFEFSPYE VGLQKYGAFI PSELFGSEFF MGRLVKRIPE SRICYMLGLW SSIFSLNLLD AWNLSHTSEE FFHRWTREKV QDIEDEPILP EIPKCDANIL ETTVVIPGSW LSNSFREILT HRSFVSEFHN FLSGLQLHTN YLQNGQFSRW KDTVLDGFPN QLTESANHLC LLDTAFFVNS SYPPLLRPER KADLIIHLNY CAGSQTKPLK QTCEYCTVQN IPFPKYELPD ENENLKECYL MENPQEPDAP IVTFFPLIND TFRKYKAPGV ERSPEELEQG QVDIYGPKTP YATKELTYTE ATFDKLVKLS EYNILNNKDT LLQALRLAVE KKKRLKGQCP S (507-856 aa encoded by BC101584)

Target Information

This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Elamipretide alleviates pyroptosis in traumatically injured spinal cord by inhibiting cPLA2-induced lysosomal membrane permeabilization.

Journal of neuroinflammation

Zhang H,Chen Y,Li F,Wu C,Cai W,Ye H,Su H,He M,Yang L,Wang X,Zhou K,Ni W

Sat Jan 07 00:00:00 UTC 2023

Inhibition of PLA2G4E/cPLA2 promotes survival of random skin flaps by alleviating Lysosomal membrane permeabilization-Induced necroptosis.

Autophagy

Lou J,Wang X,Zhang H,Yu G,Ding J,Zhu X,Li Y,Wu Y,Xu H,Xu H,Gao W,Xiao J,Zhou K

Mon Aug 01 00:00:00 UTC 2022

Group IVE cytosolic phospholipase A₂ limits psoriatic inflammation by mobilizing the anti-inflammatory lipid N-acylethanolamine.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Liang L,Takamiya R,Miki Y,Heike K,Taketomi Y,Sugimoto N,Yamaguchi M,Shitara H,Nishito Y,Kobayashi T,Hirabayashi T,Murakami M

Sun May 01 00:00:00 UTC 2022

Deletion of the Capn1 Gene Results in Alterations in Signaling Pathways Related to Alzheimer's Disease, Protein Quality Control and Synaptic Plasticity in Mouse Brain.

Frontiers in genetics

Su W,Zhou Q,Wang Y,Chishti A,Li QQ,Dayal S,Shiehzadegan S,Cheng A,Moore C,Bi X,Baudry M

Thu Apr 25 00:00:00 UTC 2024

PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment.

Progress in neurobiology