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Invitrogen
PLA2R1 Polyclonal Antibody
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FIGURE: 1 / 3
PLA2R1 Antibody (PA5-119863) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat testis tissue using PLA2R1 Polyclonal Antibody (Product # PA5-119863). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the PLA2R1 antibody at a dilution of 1:40... View More
Product Details
PA5-119863
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PLA2R amino acids 1021-1100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2913435
Product Specific Information
Positive Control: Mouse skeletal muscle tissue lysate, Raji cell lysate, rat testis tissue, SiHa.
Subcellular Location: Cell membrane, Secreted.
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor; mannose receptor, C type 2; phospholipase A2 receptor 1, 180kD; phospholipase A2 receptor 1, 180kDa; phospholipase A2, group IB, pancreas, receptor; PLA2-I receptor; PLA2-R; Secretory phospholipase A2 receptor
Gene Aliases: CLEC13C; Mrc2; PLA2-R; Pla2g1br; PLA2G1R; PLA2IR; PLA2R; PLA2R1
UniProt ID: (Human) Q13018, (Mouse) Q62028
Entrez Gene ID: (Human) 22925, (Rat) 295631, (Mouse) 18779
cytokine production
receptor-mediated endocytosis
positive regulation of DNA damage response, signal transduction by p53 class mediator
reactive oxygen species metabolic process
positive regulation of arachidonic acid secretion
replicative senescence
oxidative stress-induced premature senescence
negative regulation of phospholipase A2 activity
negative regulation of arachidonic acid secretion
endocytosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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