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Product Details
11540-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PLAGL2 Fusion Protein Ag2137 (194-496 aa encoded by BC023655)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DHCDRRFYT RKDVRRHLVV HTGRKDFLCQ YCAQRFGRKD HLTRHVKKSH SQELLKIKTE PVDMLGLLSC SSTVSVKEEL SPVLCMASRD VMGTKAFPGM LPMGMYGAHI PTMPSTGVPH SLVHNTLPMG MSYPLESSPI SSPAQLPPKY QLGSTSYLPD KLPKVEVDSF LAELPGSLSL SSAEPQPASP QPAAAAALLD EALLAKSPAN LSEALCAANV DFSHLLGFLP LNLPPCNPPG ATGGLVMGYS QAEAQPLLTT LQAQPQDSPG AGGPLNFGPL HSLPPVFTSG LSSTTLPRFH QAFQ (194-496 aa encoded by B C023655)
Target Information
The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; pleomorphic adenoma gene like 2; Zinc finger protein PLAGL2
Gene Aliases: AU018672; AW552839; KIAA0198; mKIAA0198; PLAGL2; ZNF900
UniProt ID: (Human) Q9UPG8
Entrez Gene ID: (Human) 5326, (Mouse) 54711
transcription from RNA polymerase II promoter
lipid metabolic process
post-embryonic development
chylomicron assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein targeting to mitochondrion
positive regulation of intrinsic apoptotic signaling pathway
regulation of transcription from RNA polymerase II promoter
Performance Guarantee
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