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PLAGL2 Antibody (PA5-110177) in WB
Western blot analysis of PLAGL2 in extracts of Raji cells. Samples were incubated with PLAGL2 Polyclonal antibody (Product # PA5-110177) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-110177
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 240-470 of human PLAGL2 (NP_002648.1).
Conjugate
Form
Liquid
Concentration
1.49 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2855588
Product Specific Information
Immunogen sequence: KSHSQELLKI KTEPVDMLGL LSCSSTVSVK EELSPVLCMA SRDVMGTKAF PGMLPMGMYG AHIPTMPSTG VPHSLVHNTL PMGMSYPLES SPISSPAQLP PKYQLGSTSY LPDKLPKVEV DSFLAELPGS LSLSSAEPQP ASPQPAAAAA LLDEALLAKS PANLSEALCA ANVDFSHLLG FLPLNLPPCN PPGATGGLVM GYSQAEAQPL LTTLQAQPQD SPGAGGPLNF G
Target Information
The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2
Gene Aliases: KIAA0198; PLAGL2; ZNF900
UniProt ID: (Human) Q9UPG8
Entrez Gene ID: (Human) 5326
transcription from RNA polymerase II promoter
lipid metabolic process
post-embryonic development
chylomicron assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein targeting to mitochondrion
positive regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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