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Product Details
PA5-34457
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid synthetic peptide near the amino terminus of human PLAGL2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551809
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-34457 can be used with blocking peptide PEP-1499.
Target Information
The PLAG (Pleiomorphic adenoma gene) family of zinc finger proteins include PLAG1, ZAC1 and PLAG-like 2 (PLAGL2). PLAG1 is the target gene for the pleiomorphic adenomas of the salivary gland. ZAC1 (PLAGL1) concomitantly controls apoptosis and cell cycle arrest through separate pathways. ZAC1 also acts as a transcriptional cofactor for nuclear receptors. PLAGL2 belongs to the krueppel C2H2-type zinc-finger protein family and contains 6 C2H2-type zinc fingers. It functions as a positive regulator of transcription and localizes to the nucleus. PLAGL2 is ubiquitously expressed with particular abundance in spleen, lung and testis, where it may be involved in cell cycle arrest and apoptosis of tumor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C2H2-type zinc finger protein; pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; pleomorphic adenoma gene like 2; Zinc finger protein PLAGL2
Gene Aliases: AU018672; AW552839; KIAA0198; mKIAA0198; PLAGL2; ZNF900
UniProt ID: (Human) Q9UPG8
Entrez Gene ID: (Human) 5326, (Mouse) 54711, (Rat) 296281
transcription from RNA polymerase II promoter
lipid metabolic process
post-embryonic development
chylomicron assembly
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein targeting to mitochondrion
positive regulation of intrinsic apoptotic signaling pathway
regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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