Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
AbboMax
PLC gamma 1 Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
PLC gamma 1 Antibody (500-8164) in IHC (P)
Immunohistochemistry: Human Lung Tissue (FFPE) stained with Rabbit anti-PLC-gamma (Cat# 500-8164) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
500-8164
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from internal segment of human PLC gamma 1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: Crude extract of B. cereus.
Target Information
The mammalian Phospholipase Cg (PLCg) family has two closely related proteins, PLCg1 and PLCg2. The PLCg isozymes have the core structure domains and a unique array of domains containing an additional PH domain, two SH2 domains and one SH3 domain. In response to extracellular stimuli, such as hormones and growth factors, receptor tyrosine kinases (RTKs) phosphorylate and activate PLCg. Activated PLCg catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to produce the metabolic second messenger molecules inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1; EC 3.1.4.11; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; OTTHUMP00000178982; phosphatidylinositol phospholipase C; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-1; phospholipase C, gamma 1 (formerly subtype 148); phospholipase C-1; phospholipase C-148; Phospholipase C-gamma-1; Phospholipase C-II; Phospholipase C2; PLC gamma1; PLC-148; PLC-gamma-1; PLC-II; PLC2I; triphosphoinositide phosphodiesterase
Gene Aliases: BOS_13285; NCKAP3; PLC-II; PLC1; PLC148; PLCG1; PLCgamma1; PPLCA
UniProt ID: (Bovine) P08487, (Human) P19174, (Rat) P10686
Entrez Gene ID: (Bovine) 281987, (Human) 5335, (Rat) 25738
phosphatidylinositol phospholipase C activity
signal transducer activity
calcium ion binding
phospholipid binding
phospholipase C activity
receptor signaling protein activity
neurotrophin TRKA receptor binding
protein binding
protein kinase binding
receptor tyrosine kinase binding
glutamate receptor binding
insulin receptor binding
phosphoprotein binding
in utero embryonic development
phospholipid catabolic process
positive regulation of epithelial cell migration
intracellular signal transduction
cellular response to epidermal growth factor stimulus
calcium ion transport
signal transduction
epidermal growth factor receptor signaling pathway
protein secretion
response to gravity
response to organonitrogen compound
cell migration
calcium-mediated signaling
inositol trisphosphate biosynthetic process
response to hydrogen peroxide
response to morphine
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
T cell receptor signaling pathway
positive regulation of release of sequestered calcium ion into cytosol
regulation of store-operated calcium channel activity
activation of MAPKK activity
viral process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
inositol phosphate metabolic process
leukocyte migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support