Invitrogen

PLCB1 Polyclonal Antibody

View all (10) PLCB1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-115767

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human PLCB1(Accession Q9NQ66), corresponding to amino acid residues G449-P499.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900402

Product Specific Information

Antibody detects endogenous levels of total PLCB1.

Target Information

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-1; phosphoinositide-specific phospholipase c; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; phospholipase C-beta-1a; Phospholipase C-beta1; Phospholipase C-I; PLC-154; PLC-beta-1; PLC-I; triphosphoinositide phosphodiesterase

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Gene Aliases: 3110043I21Rik; AI132408; EIEE12; KIAA0581; mKIAA0581; Phosphb; PI-PLC; PLC'1; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; PLCB1; PLCB1A; PLCB1B; PLCbeta1; RATPHOSPHB

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UniProt ID: (Human) Q9NQ66, (Rat) P10687, (Mouse) Q9Z1B3

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Entrez Gene ID: (Human) 23236, (Rat) 24654, (Mouse) 18795

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Function(s)
phosphatidylinositol phospholipase C activity signal transducer activity GTPase activator activity calcium ion binding protein binding calmodulin binding lamin binding phosphatidylinositol-4,5-bisphosphate binding enzyme binding protein homodimerization activity phosphoric diester hydrolase activity hydrolase activity
Process(es)
G2/M transition of mitotic cell cycle signal transduction G-protein coupled acetylcholine receptor signaling pathway glutamate receptor signaling pathway Wnt signaling pathway, calcium modulating pathway memory regulation of G-protein coupled receptor protein signaling pathway lipid catabolic process cerebral cortex development positive regulation of interleukin-12 production intracellular signal transduction interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway positive regulation of embryonic development positive regulation of GTPase activity inositol phosphate metabolic process fat cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of JNK cascade phosphatidylinositol metabolic process insulin-like growth factor receptor signaling pathway positive regulation of developmental growth activation of meiosis involved in egg activation interleukin-1-mediated signaling pathway regulation of fertilization positive regulation of G1/S transition of mitotic cell cycle positive regulation of acrosome reaction negative regulation of monocyte extravasation positive regulation of CD24 biosynthetic process learning response to organonitrogen compound response to monosaccharide response to peptide hormone oocyte maturation mRNA processing lipid metabolic process cell adhesion brain development insulin receptor signaling pathway erythrocyte differentiation macrophage differentiation positive regulation of sodium:proton antiporter activity regulation of cell cycle
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