Invitrogen

PLCB1 Polyclonal Antibody

View all (10) PLCB1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-119929

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-

Flow Cytometry (Flow)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein within human Phospholipase C beta 1 aa 50-250/1216
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS, pH 7.4, with 50% glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913501

Product Specific Information

Positive Control: Rat brain tissue lysate, human brain tissue lysate, mouse brain tissue lysates, rat brain tissue, mouse brain tissue, SH-SY5Y.

Subcellular Location: Nucleus membrane, Cytoplasm.

Target Information

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; inositoltrisphosphohydrolase; monophosphatidylinositol phosphodiesterase; phosphoinositidase C; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-beta-1; phosphoinositide-specific phospholipase c; phospholipase C, beta 1 (phosphoinositide-specific); Phospholipase C-beta-1; phospholipase C-beta-1a; Phospholipase C-beta1; Phospholipase C-I; PLC-154; PLC-beta-1; PLC-I; triphosphoinositide phosphodiesterase

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Gene Aliases: 3110043I21Rik; AI132408; EIEE12; KIAA0581; mKIAA0581; Phosphb; PI-PLC; PLC'1; PLC-154; PLC-beta-1; PLC-I; PLC154; Plcb; PLCB1; PLCB1A; PLCB1B; PLCbeta1; RATPHOSPHB

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UniProt ID: (Human) Q9NQ66, (Rat) P10687, (Mouse) Q9Z1B3

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Entrez Gene ID: (Human) 23236, (Rat) 24654, (Mouse) 18795

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Function(s)
phosphatidylinositol phospholipase C activity signal transducer activity GTPase activator activity calcium ion binding protein binding calmodulin binding lamin binding phosphatidylinositol-4,5-bisphosphate binding enzyme binding protein homodimerization activity phosphoric diester hydrolase activity hydrolase activity
Process(es)
G2/M transition of mitotic cell cycle signal transduction G-protein coupled acetylcholine receptor signaling pathway glutamate receptor signaling pathway Wnt signaling pathway, calcium modulating pathway memory regulation of G-protein coupled receptor protein signaling pathway lipid catabolic process cerebral cortex development positive regulation of interleukin-12 production intracellular signal transduction interleukin-12-mediated signaling pathway interleukin-15-mediated signaling pathway positive regulation of embryonic development positive regulation of GTPase activity inositol phosphate metabolic process fat cell differentiation positive regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of JNK cascade phosphatidylinositol metabolic process insulin-like growth factor receptor signaling pathway positive regulation of developmental growth activation of meiosis involved in egg activation interleukin-1-mediated signaling pathway regulation of fertilization positive regulation of G1/S transition of mitotic cell cycle positive regulation of acrosome reaction negative regulation of monocyte extravasation positive regulation of CD24 biosynthetic process learning response to organonitrogen compound response to monosaccharide response to peptide hormone oocyte maturation mRNA processing lipid metabolic process cell adhesion brain development insulin receptor signaling pathway erythrocyte differentiation macrophage differentiation positive regulation of sodium:proton antiporter activity regulation of cell cycle
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