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Invitrogen
PLCG2 Monoclonal Antibody (3A8B6)
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FIGURE: 1 / 3
PLCG2 Antibody (MA5-38599) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of PLCG2 in HeLa cells using PLCG2 Monoclonal Antibody (Product # MA5-38599) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Product # 35503)
Product Details
MA5-38599
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3A8B6
Immunogen
Synthesized peptide of human PLCG2 (cERDINSLpYDVSRMYV)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898511
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC delta1, PLC delta2 and PLCe. PLC delta exists as four different isoforms. PLC delta1, a calcium signal amplifier, is activated by an atypical GTP-binding protein. In addition, PLC delta1 is an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling. Mouse PLC delta1 is highly expressed in brain, heart, lung and testis. PLC delta is abnormally accumulated in autopsied brains with Alzheimer's disease (AD), suggesting that it may play a role in the pathology of AD. PLC delta2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma. When PLC delta2 is expressed in type I intestinal metaplasia, the metaplasia is generally considered benignant, yet evolves toward neoplastic transformation. Thus, PLC delta2 expression may be a possible marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2 (phosphatidylinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC gamma 2; PLC gamma-2; PLC gamma2; PLC- gamma2; PLC-gamma; PLC-gamma-2; PLC-IV
Gene Aliases: APLAID; FCAS3; PLC-gamma-2; PLC-IV; PLCG2
UniProt ID: (Human) P16885
Entrez Gene ID: (Human) 5336
positive regulation of receptor internalization
stimulatory C-type lectin receptor signaling pathway
follicular B cell differentiation
phosphatidylinositol biosynthetic process
phospholipid catabolic process
regulation of gene expression
Wnt signaling pathway
calcium-mediated signaling
platelet activation
B cell differentiation
activation of store-operated calcium channel activity
positive regulation of type I interferon production
response to lipopolysaccharide
inositol trisphosphate biosynthetic process
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of programmed cell death
inositol phosphate metabolic process
T cell receptor signaling pathway
B cell receptor signaling pathway
release of sequestered calcium ion into cytosol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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