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Invitrogen
PLCG2 Recombinant Rabbit Monoclonal Antibody (7I1C9)
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Product Details
MA5-35670
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7I1C9
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human PLC gamma 2 (PLC gamma 2 (PLCG2)) (P16885)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849570
Product Specific Information
Immunogen sequence: RHFVLGTSAY FESLVELVSY YEKHSLYRKM RLRYPVTPEL LERYNMERDI NSLYDVSRMY VDPSEINPSM PQRTVKALYD YKAKRSDELS FCRGALIHNV S
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC beta1, PLC beta2, PLC beta3, PLC beta4, PLC gamma1, PLC gamma2, PLC delta1, PLC delta2 and PLCe. PLC delta exists as four different isoforms. PLC delta1, a calcium signal amplifier, is activated by an atypical GTP-binding protein. In addition, PLC delta1 is an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and alpha1B-adrenoreceptor signaling. Mouse PLC delta1 is highly expressed in brain, heart, lung and testis. PLC delta is abnormally accumulated in autopsied brains with Alzheimer's disease (AD), suggesting that it may play a role in the pathology of AD. PLC delta2 is markedly expressed in type II intestinal metaplasia and in the adenocarcinoma. When PLC delta2 is expressed in type I intestinal metaplasia, the metaplasia is generally considered benignant, yet evolves toward neoplastic transformation. Thus, PLC delta2 expression may be a possible marker of gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-2; phospholipase C, gamma 2 (phosphatidylinositol-specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC gamma 2; PLC gamma-2; PLC gamma2; PLC- gamma2; PLC-gamma; PLC-gamma-2; PLC-IV
Gene Aliases: APLAID; FCAS3; PLC-gamma-2; PLC-IV; Plcg-2; PLCG2; PLCgamma2
UniProt ID: (Human) P16885, (Rat) P24135, (Mouse) Q8CIH5
Entrez Gene ID: (Human) 5336, (Rat) 29337, (Mouse) 234779
follicular B cell differentiation
phosphatidylinositol biosynthetic process
positive regulation of cytosolic calcium ion concentration
phospholipid catabolic process
regulation of gene expression
B cell differentiation
response to magnesium ion
activation of store-operated calcium channel activity
response to lipopolysaccharide
inositol trisphosphate biosynthetic process
response to ATP
intracellular signal transduction
negative regulation of programmed cell death
T cell receptor signaling pathway
B cell receptor signaling pathway
release of sequestered calcium ion into cytosol
lipid metabolic process
signal transduction
lipid catabolic process
positive regulation of receptor internalization
stimulatory C-type lectin receptor signaling pathway
Wnt signaling pathway
calcium-mediated signaling
platelet activation
positive regulation of type I interferon production
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
inositol phosphate metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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