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The antibody detects endogenous levels of total PLCZ1 protein.
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; Phosphoinositide phospholipase C-zeta-1; phospholipase C, zeta 1; Phospholipase C-zeta-1; PI-phospholipase C zeta 1; PLC-zeta-1; PLCZ1; testicular tissue protein Li 145; Testis-development protein NYD-SP27; testis-development related NYD-SP27
Gene Aliases: NYD-SP27; PLC-zeta-1; PLCZ1; PLCzeta
UniProt ID: (Human) Q86YW0
Entrez Gene ID: (Human) 89869
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