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Invitrogen
PLD6 Polyclonal Antibody
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Product Details
PA5-61939
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PLD6. Recombinant protein control fragment (Product #RP-90525).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645643
Product Specific Information
Immunogen sequence: QDPGYMHHKF AIVDKRVLIT GSLNWTTQAI QNNRENVLIT EDDEYVRLFL EEFERIWEQF NPTKYTFFPP KKSHGSCAPP VSRAGGRLLS WHRTCGTSSE SQT
Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 61%.
Target Information
PLD6 is a cardiolipin hydrolase present at the mitochondrial outer membrane required both for mitochondrial fusion and piRNA metabolic process. PLD6 acts by catalyzing the hydrolysis of cardiolipin (diphosphatidylglycerol) to form phosphatidate (phosphatidic acid or PA) at the mitochondrial outer membrane surface, promoting mitochondrial fusion. The production of phosphatidate also regulates the piRNA metabolic process by promoting recruitment and/or activation of components of the meiotic nuage, also named P granule, a critical step for primary biogenesis of piRNAs. It is required during spermatogenesis to repress transposable elements and prevent their mobilization via its role in the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Choline phosphatase 6; Mitochondrial cardiolipin hydrolase; Mitochondrial phospholipase; MitoPLD; Phosphatidylcholine-hydrolyzing phospholipase D6; phospholipase D family, member 6; Phospholipase D6; PLD 6; PLD6; Protein zucchini homolog
Gene Aliases: PLD6; ZUC
UniProt ID: (Human) Q8N2A8
Entrez Gene ID: (Human) 201164
meiotic nuclear division
spermatid development
mitochondrial fusion
positive regulation of mitochondrial fusion
lipid catabolic process
P granule organization
cardiolipin biosynthetic process
piRNA metabolic process
DNA methylation involved in gamete generation
RNA phosphodiester bond hydrolysis, endonucleolytic
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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