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PLEK2 Polyclonal Antibody

PLEK2 Antibody in Immunocytochemistry (ICC/IF)

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PLEK2 Antibody (11685-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed HT-29 cells using PLEK2 antibody (Product # 11685-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PLEK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11685-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PLEK2 Fusion Protein Ag2297 (90-353 aa encoded by BC001226)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EERDAWAFE ITGAIHAGQP GKVQQLHSLR NSFKLPPHIS LHRIVDKMHD SNTGIRSSPN MEQGSTYKKT FLGSSLVDWL ISNSFTASRL EAVTLASMLM EENFLRPVGV RSMGAIRSGD LAEQFLDDST ALYTFAESYK KKISPKEEIS LSTVELSGTV VKQGYLAKQG HKRKNWKVRR FVLRKDPAFL HYYDPSKEEN RPVGGFSLRG SLVSALEDNG VPTGVKGNVQ GNLFKVITKD DTHYYIQASS KAERAEWIEA IKKLT (90-353 aa encoded by B C001226)

Target Information

Pleckstrin 2 may help orchestrate cytoskeletal arrangement and contribute to lamellipodia formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.

The Journal of clinical investigation

Han X,Mei Y,Mishra RK,Bi H,Jain AD,Schiltz GE,Zhao B,Sukhanova M,Wang P,Grigorescu AA,Weber PC,Piwinski JJ,Prado MA,Paulo JA,Stephens L,Anderson KE,Abrams CS,Yang J,Ji P

Wed Mar 15 00:00:00 UTC 2023

Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models.

The Journal of clinical investigation

Han X,Mei Y,Mishra RK,Bi H,Jain AD,Schiltz GE,Zhao B,Sukhanova M,Wang P,Grigorescu AA,Weber PC,Piwinski JJ,Prado MA,Paulo JA,Stephens L,Anderson KE,Abrams CS,Yang J,Ji P

Wed Mar 15 00:00:00 UTC 2023

PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.

Cancer communications (London, England)

Zhao X,Shu D,Sun W,Si S,Ran W,Guo B,Cui L

Sat Oct 01 00:00:00 UTC 2022

Pleckstrin-2 as a Prognostic Factor and Mediator of Gastric Cancer Progression.

Gastroenterology research and practice

Wang J,He Z,Sun B,Huang W,Xiang J,Chen Z,Li Z,Gu X

Tue Aug 17 00:00:00 UTC 2021

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.

Communications biology

Feola M,Zamperone A,Moskop D,Chen H,Casu C,Lama D,Di Martino J,Djedaini M,Papa L,Martinez MR,Choesang T,Bravo-Cordero JJ,MacKay M,Zumbo P,Brinkman N,Abrams CS,Rivella S,Hattangadi S,Mason CE,Hoffman R,Ji P,Follenzi A,Ginzburg YZ

Mon May 03 00:00:00 UTC 2021

Pleckstrin-2 is essential for erythropoiesis in β-thalassemic mice, reducing apoptosis and enhancing enucleation.

Communications biology

Mon May 03 00:00:00 UTC 2021

microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway.

Cellular signalling

Yang XL,Ma YS,Liu YS,Jiang XH,Ding H,Shi Y,Jia CY,Lu GX,Zhang DD,Wang HM,Wang PY,Lv ZW,Yu F,Liu JB,Fu D

Sun Aug 01 00:00:00 UTC 2021

microRNA-873 inhibits self-renewal and proliferation of pancreatic cancer stem cells through pleckstrin-2-dependent PI3K/AKT pathway.

Cellular signalling

Yang XL,Ma YS,Liu YS,Jiang XH,Ding H,Shi Y,Jia CY,Lu GX,Zhang DD,Wang HM,Wang PY,Lv ZW,Yu F,Liu JB,Fu D

Sun Aug 01 00:00:00 UTC 2021

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.

Oncology letters

Liu Y,Yang S,Wang F,Zhou Z,Xu W,Xie J,Qiao L,Gu Y

Thu Jul 01 00:00:00 UTC 2021

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.

Oncology letters

Liu Y,Yang S,Wang F,Zhou Z,Xu W,Xie J,Qiao L,Gu Y

Thu Jul 01 00:00:00 UTC 2021

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.

Oncology letters

Liu Y,Yang S,Wang F,Zhou Z,Xu W,Xie J,Qiao L,Gu Y

Thu Jul 01 00:00:00 UTC 2021

PLEK2 promotes osteosarcoma tumorigenesis and metastasis by activating the PI3K/AKT signaling pathway.

Oncology letters

Liu Y,Yang S,Wang F,Zhou Z,Xu W,Xie J,Qiao L,Gu Y

Thu Jul 01 00:00:00 UTC 2021

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.

Cell death & disease

Wang F,Zhang C,Cheng H,Liu C,Lu Z,Zheng S,Wang S,Sun N,He J

Sat Oct 02 00:00:00 UTC 2021

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.

Cell death & disease

Wang F,Zhang C,Cheng H,Liu C,Lu Z,Zheng S,Wang S,Sun N,He J

Sat Oct 02 00:00:00 UTC 2021

PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.

Journal of experimental & clinical cancer research : CR

Shen H,He M,Lin R,Zhan M,Xu S,Huang X,Xu C,Chen W,Yao Y,Mohan M,Wang J

Mon Jun 10 00:00:00 UTC 2019

PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway.

Journal of experimental & clinical cancer research : CR

Shen H,He M,Lin R,Zhan M,Xu S,Huang X,Xu C,Chen W,Yao Y,Mohan M,Wang J

Mon Jun 10 00:00:00 UTC 2019

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 UTC 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 UTC 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 UTC 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

Tue Jan 02 00:00:00 UTC 2018

Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta.

Biology of reproduction

DaSilva-Arnold SC,Zamudio S,Al-Khan A,Alvarez-Perez J,Mannion C,Koenig C,Luke D,Perez AM,Petroff M,Alvarez M,Illsley NP

Wed Aug 01 00:00:00 UTC 2018

Human trophoblast epithelial-mesenchymal transition in abnormally invasive placenta.

Biology of reproduction

DaSilva-Arnold SC,Zamudio S,Al-Khan A,Alvarez-Perez J,Mannion C,Koenig C,Luke D,Perez AM,Petroff M,Alvarez M,Illsley NP

Wed Aug 01 00:00:00 UTC 2018

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

Haematologica

Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

Tue Jul 01 00:00:00 UTC 2014

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

Haematologica

Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

Tue Jul 01 00:00:00 UTC 2014

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

Haematologica

Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

Tue Jul 01 00:00:00 UTC 2014

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

Haematologica

Zhao B,Keerthivasan G,Mei Y,Yang J,McElherne J,Wong P,Doench JG,Feng G,Root DE,Ji P

Tue Jul 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: pleckstrin 2 homolog; Pleckstrin-2

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Gene Aliases: PLEK2

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UniProt ID: (Human) Q9NYT0, (Mouse) Q9WV52

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Entrez Gene ID: (Human) 26499, (Mouse) 27260, (Rat) 314260

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Process(es)

intracellular signal transduction actin cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PLEK2 Polyclonal Antibody

PLEK2 Antibody (11685-1-AP) in ICC/IF

Product Details

11685-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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