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OriGene
PLIN5 Monoclonal Antibody (OTI3G4), TrueMAB™
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Product Details
TA811701
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3G4
Immunogen
Human recombinant protein fragment corresponding to amino acids 1-463 of human PLIN5 produced in E.coli.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lipid storage droplet protein 5; Perilipin-5
Gene Aliases: LSDA5; LSDP5; MLDP; OXPAT; PAT-1; PLIN5
UniProt ID: (Human) Q00G26
Entrez Gene ID: (Human) 440503
positive regulation of triglyceride biosynthetic process
positive regulation of lipid storage
positive regulation of sequestering of triglyceride
negative regulation of triglyceride catabolic process
lipid storage
negative regulation of fatty acid beta-oxidation
positive regulation of fatty acid beta-oxidation
lipid particle organization
negative regulation of peroxisome proliferator activated receptor signaling pathway
mitochondrion localization
negative regulation of lipase activity
positive regulation of lipase activity
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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