Proteintech

PLK3 Polyclonal Antibody

PLK3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PLK3 Antibody (10977-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 10977-1-AP (PLK3 antibody) at dilution of 1:10 (under 10x lens).

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Product Details

10977-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PLK3 Fusion Protein Ag1431 (298-646 aa encoded by BC013899)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SPRDRPSID QILRHDFFTK GYTPDRLPIS SCVTVPDLTP PNPARSLFAK VTKSLFGRKK KSKNHAQERD EVSGLVSGLM RTSVGHQDAR PEAPAASGPA PVSLVETAPE DSSPRGTLAS SGDGFEEGLT VATVVESALC ALRNCIAFMP PAEQNPAPLA QPEPLVWVSK WVDYSNKFGF GYQLSSRRVA VLFNNGTHMA LSANRKTVHY NPTSTKHFSF SVGAVPRALQ PQLGILRYFA SYMEQHLMKG GDLPSVEEVE VPAPPLLLQW VKTDQALLML FSDGTVQVNF YGDHTKLILS GWEPLLVTFV ARNRSACTYL ASHLRQLGCS PDLRQRLRYA LRLLRDRSPA (298-646 aa encoded by BC013899)

Target Information

PLK3 is a member of the polo family of serine/threonine kinases. PLK3 is involved in the regulation of M phase in the cell cycle. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The mechanism of acentrosomal spindle assembly in human oocytes.

Science (New York, N.Y.)

Wu T,Dong J,Fu J,Kuang Y,Chen B,Gu H,Luo Y,Gu R,Zhang M,Li W,Dong X,Sun X,Sang Q,Wang L

Fri Nov 18 00:00:00 UTC 2022

Prognostic significance of polo-like kinases in retinoblastoma: correlation with patient outcome, clinical and histopathological parameters.

Clinical & experimental ophthalmology

Singh L,Pushker N,Sen S,Singh MK,Chauhan FA,Kashyap S

Sat Aug 01 00:00:00 UTC 2015

Prognostic significance of polo-like kinases in retinoblastoma: correlation with patient outcome, clinical and histopathological parameters.

Clinical & experimental ophthalmology

Singh L,Pushker N,Sen S,Singh MK,Chauhan FA,Kashyap S

Sat Aug 01 00:00:00 UTC 2015

Polo-like kinase 3 is associated with improved overall survival in cholangiocarcinoma.

Liver international : official journal of the International Association for the Study of the Liver

Juntermanns B,Sydor S,Kaiser GM,Jaradat D,Mertens JC,Sotiropoulos GC,Swoboda S,Neuhaus JP,Meng W,Mathé Z,Baba HA,Canbay A,Paul A,Fingas CD

Sun Nov 01 00:00:00 UTC 2015

Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.

Hepatology (Baltimore, Md.)

Fingas CD,Mertens JC,Razumilava N,Sydor S,Bronk SF,Christensen JD,Ilyas SI,Canbay A,Treckmann JW,Paul A,Sirica AE,Gores GJ

Tue Oct 01 00:00:00 UTC 2013

Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.

Hepatology (Baltimore, Md.)

Fingas CD,Mertens JC,Razumilava N,Sydor S,Bronk SF,Christensen JD,Ilyas SI,Canbay A,Treckmann JW,Paul A,Sirica AE,Gores GJ

Tue Oct 01 00:00:00 UTC 2013

Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.

Hepatology (Baltimore, Md.)

Fingas CD,Mertens JC,Razumilava N,Sydor S,Bronk SF,Christensen JD,Ilyas SI,Canbay A,Treckmann JW,Paul A,Sirica AE,Gores GJ

Tue Oct 01 00:00:00 UTC 2013

Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.

Hepatology (Baltimore, Md.)

Fingas CD,Mertens JC,Razumilava N,Sydor S,Bronk SF,Christensen JD,Ilyas SI,Canbay A,Treckmann JW,Paul A,Sirica AE,Gores GJ

Tue Oct 01 00:00:00 UTC 2013

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

Molecular and cellular biology

López-Sánchez I,Sanz-García M,Lazo PA

Sun Mar 01 00:00:00 UTC 2009

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

Molecular and cellular biology

López-Sánchez I,Sanz-García M,Lazo PA

Sun Mar 01 00:00:00 UTC 2009

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

Molecular and cellular biology

López-Sánchez I,Sanz-García M,Lazo PA

Sun Mar 01 00:00:00 UTC 2009

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

Molecular and cellular biology

López-Sánchez I,Sanz-García M,Lazo PA

Sun Mar 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: cytokine inducible kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; PLK-3; Polo-like kinase 3; Proliferation-related kinase; serine-threonine kinase; Serine/threonine-protein kinase PLK3

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Gene Aliases: CNK; FNK; PLK-3; PLK3; PRK

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UniProt ID: (Human) Q9H4B4, (Rat) Q9R011

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Entrez Gene ID: (Human) 1263, (Rat) 58936, (Mouse) 12795

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Function(s)

p53 binding protein serine/threonine kinase activity protein binding ATP binding protein kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter response to reactive oxygen species protein phosphorylation apoptotic process response to osmotic stress cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic cell cycle checkpoint endomitotic cell cycle response to radiation cytoplasmic microtubule organization regulation of cytokinesis negative regulation of apoptotic process protein kinase B signaling mitotic G1/S transition checkpoint regulation of cell division Golgi disassembly positive regulation of intracellular protein transport regulation of signal transduction by p53 class mediator positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity cell cycle phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PLK3 Polyclonal Antibody

PLK3 Antibody (10977-1-AP) in IHC (P)

Product Details

10977-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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