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Invitrogen
PLP1 Monoclonal Antibody (plpc 1)
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FIGURE: 1 / 2
PLP1 Antibody (MA1-90652) in ICC/IF
Immunofluorescence analysis of PLP1 was performed using 70% confluent log phase Hep G2 and PC-3 cells. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with PLP1 Monoclonal Antibody (plpc 1) (Product # MA1-90652) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 ... View More
Product Details
MA1-90652
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
plpc 1
Immunogen
Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1958387
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lipophilin; major myelin proteolipid protein; Myelin proteolipid protein; PLP; proteolipid
Gene Aliases: BOS_25620; GPM6C; HLD1; MMPL; PLP; PLP/DM20; PLP1; PMD; SPG2
UniProt ID: (Bovine) P04116, (Human) P60201
Entrez Gene ID: (Bovine) 281410, (Human) 5354
positive regulation of gene expression
central nervous system myelination
long-chain fatty acid biosynthetic process
cell maturation
inflammatory response
integrin-mediated signaling pathway
chemical synaptic transmission
axon ensheathment
astrocyte development
substantia nigra development
axon development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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