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Product Details
12917-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PLS3 Fusion Protein Ag3574 (281-630 aa encoded by BC039049)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LENSGWQKI NNFSADIKDS KAYFHLLNQI APKGQKEGEP RIDINMSGFN ETDDLKRAES MLQQADKLGC RQFVTPADVV SGNPKLNLAF VANLFNKYPA LTKPENQDID WTLLEGETRE ERTFRNWMNS LGVNPHVNHL YADLQDALVI LQLYERIKVP VDWSKVNKPP YPKLGANMKK LENCNYAVEL GKHPAKFSLV GIGGQDLNDG NQTLTLALVW QLMRRYTLNV LEDLGDGQKA NDDIIVNWVN RTLSEAGKST SIQSFKDKTI SSSLAVVDLI DAIQPGCINY DLVKSGNLTE DDKHNNAKYA VSMARRIGAR VYALPEDLVE VKPKMVMTVF ACLMGRGMKR V (281-630 aa encoded by BC039049)
Target Information
Phospholipid scramblases (PLS) translocate phospholipids bidirectionally between inner and outer leaflets of the plasma membrane and are implicated in apoptosis (1,2). Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: plastin 3 (T-isoform); plastin 3, T; Plastin-3; T fimbrin; T plastin; T-fimbrin; T-plastin
Gene Aliases: AI115446; AL024105; BMND18; PLS3; T-fimbrin; T-plastin
UniProt ID: (Human) P13797, (Mouse) Q99K51
Entrez Gene ID: (Human) 5358, (Rat) 81748, (Mouse) 102866
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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