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Invitrogen
PLZF Monoclonal Antibody (6318100), APC
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PLZF Antibody (MA5-23681) in Flow
Flow cytometry of PLZF in HL‚60 human acute promyelocytic leukemia cell line. Samples were incubated in PLZF monoclonal antibody (Product # MA5-23681) or isotype control. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Product Details
MA5-23681
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
6318100
Immunogen
E. coli-derived recombinant human PLZF Met1-Gln254
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
Buffered saline solution with BSA
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608110
Product Specific Information
In direct ELISAs, no cross-reactivity with recombinant human (rh) ZBTB38, rhZNF24, rhZNF143, rhZNF206, rhZNF281, or rhZNF423 is observed.
Target Information
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: promyelocytic leukaemia zinc finger; Promyelocytic leukemia zinc finger protein; Zinc finger and BTB domain-containing protein 16; Zinc finger protein 145; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); Zinc finger protein PLZF
Gene Aliases: PLZF; ZBTB16; ZNF145
UniProt ID: (Human) Q05516
Entrez Gene ID: (Human) 7704
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
protein binding
protein C-terminus binding
protein domain specific binding
identical protein binding
protein homodimerization activity
metal ion binding
negative regulation of transcription from RNA polymerase II promoter
mesonephros development
transcription, DNA-templated
apoptotic process
central nervous system development
negative regulation of cell proliferation
embryonic pattern specification
anterior/posterior pattern specification
protein ubiquitination
hemopoiesis
myeloid cell differentiation
positive regulation of chondrocyte differentiation
protein localization to nucleus
embryonic hindlimb morphogenesis
forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of apoptotic process
positive regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of ossification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
male germ-line stem cell asymmetric division
positive regulation of NK T cell differentiation
cartilage development
positive regulation of cartilage development
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