Invitrogen

PMCA ATPase Polyclonal Antibody

View all (4) PMCA ATPase antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-107073

Applications
Tested Dilution
Publications

Western Blot (WB)

0.2-1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide directed towards the middle region of human ATP2B4 (aa 936-985)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.4, with 2% sucrose

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817789

Product Specific Information

Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Immunogen sequence: FAGEKFFDID SGRKAPLHSP PSQHYTIVFN TFVLMQLFNE INSRKIHGEK

Target Information

The calcium pump of the plasma membrane (PMCA ATPase) pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the sarcoplasmic and endoplasmic reticulum calcium (SERCA) ATPase and the sodium/potassium pump. Studies indicate that there are four known isoforms of the PMCA ATPase which are encoded by a multigene family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase, Ca++ transporting, plasma membrane 1; ATPase, Ca++ transporting, plasma membrane 2; ATPase, Ca++ transporting, plasma membrane 3; ATPase, Ca++ transporting, plasma membrane 4; cilia and flagella associated protein 39; Matrix-remodeling-associated protein 1; plasma membrane Ca(2+)-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; Plasma membrane calcium pump isoform 2; Plasma membrane calcium pump isoform 3; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 1; Plasma membrane calcium-transporting ATPase 2; Plasma membrane calcium-transporting ATPase 3; Plasma membrane calcium-transporting ATPase 4; PMCA1; PMCA2; PMCA3; PMCA4; sarcolemmal calcium pump

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Gene Aliases: ATP2B1; ATP2B2; ATP2B3; ATP2B4; CFAP39; CLA2; MXRA1; OPCA; PMCA1; PMCA1kb; PMCA2; PMCA2a; PMCA2i; PMCA3; PMCA3a; PMCA4; PMCA4b; PMCA4x; SCAX1

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UniProt ID: (Human) P20020, (Human) Q01814, (Human) Q16720, (Human) P23634

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Entrez Gene ID: (Human) 490, (Human) 491, (Human) 492, (Human) 493

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Function(s)
calcium-transporting ATPase activity protein binding calmodulin binding ATP binding PDZ domain binding metal ion binding calcium-dependent ATPase activity sodium channel regulator activity protein phosphatase 2B binding nitric-oxide synthase inhibitor activity nitric-oxide synthase binding scaffold protein binding
Process(es)
neural retina development transport cellular calcium ion homeostasis brain development aging response to cold ion transmembrane transport calcium ion transmembrane transport cellular response to vitamin D cellular response to corticosterone stimulus calcium ion export regulation of cardiac conduction calcium ion transport organelle organization lactation sensory perception of sound locomotory behavior regulation of cell size cerebellar Purkinje cell differentiation cerebellar granule cell differentiation neuron differentiation locomotion serotonin metabolic process otolith mineralization cGMP metabolic process regulation of synaptic plasticity synapse organization neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport auditory receptor cell stereocilium organization cochlea development regulation of transcription from RNA polymerase II promoter spermatogenesis negative regulation of nitric oxide mediated signal transduction hippocampus development sperm motility positive regulation of peptidyl-serine phosphorylation negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity response to hydrostatic pressure negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus calcium ion transmembrane import into cytosol calcium ion import across plasma membrane negative regulation of the force of heart contraction negative regulation of arginine catabolic process negative regulation of adrenergic receptor signaling pathway involved in heart process negative regulation of peptidyl-cysteine S-nitrosylation regulation of sodium ion transmembrane transport regulation of cell cycle G1/S phase transition negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process positive regulation of cAMP-dependent protein kinase activity
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