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OriGene
PML Recombinant Rabbit Monoclonal Antibody (OTIR1H2), TrueRAB™
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Product Details
TA591018
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
OTIR1H2
Immunogen
Synthetic peptide APASEEEFQFLR. The antigen corresponds to amino acid range 12-56 of the target protein.
Conjugate
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Application for antibody includes Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA).
Target Information
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 SUMO-protein ligase PML; PML/RARA fusion; pml1; probable transcription factor PML; Promyelocytic leukemia protein; promyelocytic leukemia, inducer of; Protein PML; RING finger protein 71; RING-type E3 SUMO transferase PML; TRIM19; tripartite motif protein TRIM19; Tripartite motif-containing protein 19
Gene Aliases: MYL; PML; PP8675; RNF71; TRIM19
UniProt ID: (Human) P29590
Entrez Gene ID: (Human) 5371
response to hypoxia
regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein complex assembly
activation of cysteine-type endopeptidase activity involved in apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
cell cycle arrest
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein import into nucleus
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
response to UV
response to gamma radiation
regulation of calcium ion transport into cytosol
fibroblast migration
negative regulation of angiogenesis
protein sumoylation
myeloid cell differentiation
regulation of cell adhesion
negative regulation of cell growth
PML body organization
positive regulation of telomere maintenance
endoplasmic reticulum calcium ion homeostasis
circadian regulation of gene expression
response to cytokine
regulation of circadian rhythm
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
innate immune response
cell fate commitment
regulation of MHC class I biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of fibroblast proliferation
retinoic acid receptor signaling pathway
negative regulation of interleukin-1 beta secretion
maintenance of protein location in nucleus
defense response to virus
interferon-gamma-mediated signaling pathway
branching involved in mammary gland duct morphogenesis
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to interleukin-4
cellular senescence
extrinsic apoptotic signaling pathway
regulation of signal transduction by p53 class mediator
negative regulation of viral release from host cell
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of double-strand break repair
positive regulation of extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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