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PMS2 Monoclonal Antibody (1G4E6)

PMS2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PMS2 Antibody (66075-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using 66075-1-IG ( PMS2 Antibody) at dilution of 1:400 (under 40x lens).

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Product Details

66075-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1G4E6

Immunogen

PMS2 Fusion Protein Ag12661 (513-862 aa encoded by BC093921)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.58 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SHCSSEYAA SSPGDRGSQE HVDSQEKAPE TDDSFSDVDC HSNQEDTGCK FRVLPQPTNL ATPNTKRFKK EEILSSSDIC QKLVNTQDMS ASQVDVAVKI NKKVVPLDFS ISSLAKRIKQ LHHEAQQSEG EQNYRKFRAK ICPGENQAAE DELRKEISKT MFAEMEIIGQ FNLGFIITKL NEDIFIVDQH ATDEKYNFEM LQQHTVLQGQ RLIAPQTLNL TAVNEAVLIE NLEIFRKNGF DFVIDENAPV TERAKLISLP TSKNWTFGPQ DVDELIFMLS DSPGVMCRPS RVKQMFASRA CRKSVMIGTA LNTSEMKKLI THMGEMDHPW NCPHGRPTMR HIANLGVISQ N (513-862 aa encoded by BC093921)

Target Information

PMS1 protein homologue 2 (PMS2) is a DNA mismatch repair protein. Defects in PMS2 are a cause of hereditary non-polyposis cancer (HNPCC). Human PMS2 is an amino acid protein of 862 amino acids.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma.

Scientific reports

Ganesa S,Sule A,Sundaram RK,Bindra RS

Wed Apr 06 00:00:00 UTC 2022

Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.

Cancer immunology research

Wu Q,Huang Q,Jiang Y,Sun F,Liang B,Wang J,Hu X,Sun M,Ma Z,Shi Y,Liang Y,Tan Y,Zeng D,Yao F,Xu X,Yao Z,Li S,Rong X,Huang N,Sun L,Liao W,Shi M

Tue Feb 01 00:00:00 UTC 2022

Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence.

Frontiers in oncology

Ran X,Hu T,Li Z

Sat Jul 16 00:00:00 UTC 2022

Sebaceous adenoma occurring within an intracranial dermoid cyst.

Neuropathology : official journal of the Japanese Society of Neuropathology

Minamisaka T,Imura J,Shiraishi K,Takagi K,Tomia T,Tanaka S,Noguchi A,Akai T,Noguchi K,Kuroda S

Mon Aug 01 00:00:00 UTC 2022

Mismatch repair deficiency in canine neoplasms.

Veterinary pathology

Inanaga S,Igase M,Sakai Y,Tanabe M,Shimonohara N,Itamoto K,Nakaichi M,Mizuno T

Mon Nov 01 00:00:00 UTC 2021

Clinicopathological and survival characteristic of mismatch repair status in ovarian clear cell carcinoma.

Journal of surgical oncology

Zhu J,Ke G,Bi R,Wu X

Tue Sep 01 00:00:00 UTC 2020

PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.

Molecular genetics & genomic medicine

Guo X,Wu W,Gao H,Li X,He Q,Zhu Y,Liu N

Sat Jun 01 00:00:00 UTC 2019

PMS2 germline mutation c.943C>T (p.Arg315*)-induced Lynch syndrome-associated ovarian cancer.

Molecular genetics & genomic medicine

Guo X,Wu W,Gao H,Li X,He Q,Zhu Y,Liu N

Sat Jun 01 00:00:00 UTC 2019

Mismatch repair status as a beneficial predictor of fluorouracil-based adjuvant chemotherapy for pancreatic cancer.

Surgery

Liang D,Shi S,Liang C,Meng Q,Zhang B,Ni Q,Xu J,Yu X

Tue May 01 00:00:00 UTC 2018

Mismatch repair status as a beneficial predictor of fluorouracil-based adjuvant chemotherapy for pancreatic cancer.

Surgery

Liang D,Shi S,Liang C,Meng Q,Zhang B,Ni Q,Xu J,Yu X

Tue May 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: DNA mismatch repair protein PMS2; H_DJ0042M02.9; Mismatch repair endonuclease PMS2; PMS1 homolog 2, mismatch repair protein; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2; postmeiotic segregation increased 2 nirs variant 6

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Gene Aliases: AW555130; HNPCC4; MLH4; PMS2; PMS2CL; PMSL2

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UniProt ID: (Human) P54278, (Mouse) P54279

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Entrez Gene ID: (Human) 5395, (Rat) 288479, (Mouse) 18861

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Function(s)

DNA binding single-stranded DNA binding endonuclease activity protein binding ATP binding ATPase activity single base insertion or deletion binding MutSalpha complex binding molecular_function nuclease activity hydrolase activity mismatched DNA binding

Process(es)

DNA repair mismatch repair cellular response to DNA damage stimulus somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments response to drug nucleic acid phosphodiester bond hydrolysis meiotic nuclear division

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PMS2 Monoclonal Antibody (1G4E6)

PMS2 Antibody (66075-1-IG) in IHC (P)

Product Details

66075-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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