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Proteintech
PNKP Polyclonal Antibody
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Product Details
13558-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PNKP Fusion Protein Ag4421 (171-521 aa encoded by BC033822)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DLDGTLITT RSGKVFPTGP SDWRILYPEI PRKLRELEAE GYKLVIFTNQ MSIGRGKLPA EEFKAKVEAV VEKLGVPFQV LVATHAGLYR KPVTGMWDHL QEQANDGTPI SIGDSIFVGD AAGRPANWAP GRKKKDFSCA DRLFALNLGL PFATPEEFFL KWPAAGFELP AFDPRTVSRS GPLCLPESRA LLSASPEVVV AVGFPGAGKS TFLKKHLVSA GYVHVNRDTL GSWQRCVTTC ETALKQGKRV AIDNTNPDAA SRARYVQCAR AAGVPCRCFL FTATLEQARH NNRFREMTDS SHIPVSDMVM YGYRKQFEAP TLAEGFSAIL EIPFRLWVEP RLGRLYCQFS EG (171-521 aa encoded by BC033822)
Target Information
Anti-human Polynucleotide Kinase Mouse Monoclonal Antibody recognizes polynucleotide kinase (PNK), a 57 kDa nuclear enzyme implicated in DNA strand repair processes that occur during DNA replication and recombination, or in response to DNA damaging agents. PNK targets the DNA 5'-hydroxy and 3'-phosphate termini for phosphorylation and dephosphorylation events. During strand breakage in human cells, normal PNK associates with other nuclear proteins to prepare the DNA termini for the enzymatic actions of DNA polymerase-beta and DNA ligase III. PNK is a key functional component in maintaining the genetic stability of human cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); phosphatase/kinase; PKNP; Polynucleotide kinase-3'-phosphatase
Gene Aliases: 1810009G08Rik; AOA4; EIEE10; MCSZ; PNK; PNKP
UniProt ID: (Human) Q96T60
Entrez Gene ID: (Human) 11284, (Mouse) 59047, (Rat) 308576
damaged DNA binding
double-stranded DNA binding
endonuclease activity
protein binding
ATP binding
purine nucleotide binding
nucleotide kinase activity
polynucleotide 3'-phosphatase activity
ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
nucleotide binding
catalytic activity
kinase activity
transferase activity
hydrolase activity
molecular_function
nucleotide-excision repair, DNA damage removal
DNA-dependent DNA replication
DNA repair
response to oxidative stress
response to radiation
dephosphorylation
positive regulation of telomere maintenance via telomerase
DNA damage response, detection of DNA damage
nucleotide phosphorylation
positive regulation of telomerase activity
nucleic acid phosphodiester bond hydrolysis
DNA 3' dephosphorylation involved in DNA repair
polynucleotide 3' dephosphorylation
positive regulation of telomere capping
cellular response to DNA damage stimulus
metabolic process
phosphorylation
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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