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Proteintech
PNMA2 Polyclonal Antibody
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Product Details
16445-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PNMA2 Fusion Protein Ag10289 (1-364 aa encoded by BC062301)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MALALLEDW CRIMSVDEQK SLMVTGIPAD FEEAEIQEVL QETLKSLGRY RLLGKIFRKQ ENANAVLLEL LEDTDVSAIP SEVQGKGGVW KVIFKTPNQD TEFLERLNLF LEKEGQTVSG MFRALGQEGV SPATVPCISP ELLAHLLGQA MAHAPQPLLP MRYRKLRVFS GSAVPAPEEE SFEVWLEQAT EIVKEWPVTE AEKKRWLAES LRGPALDLMH IVQADNPSIS VEECLEAFKQ VFGSLESRRT AQVRYLKTYQ EEGEKVSAYV LRLETLLRRA VEKRAIPRRI ADQVRLEQVM AGATLNQMLW CRLRELKDQG PPPSFLELMK VIREEEEEEA SFENESIEEP EERDGYGRWN HEGDD (1-364 aa encoded by BC062301)
Target Information
In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a "brain-testis-cancer" gene related to other para-neoplastic syndromes and tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 40 kDa neuronal protein; Onconeuronal antigen Ma2; Paraneoplastic antigen Ma2; Paraneoplastic antigen Ma2 homolog; Paraneoplastic neuronal antigen MM2; retrotransposon gag domain containing 2
Gene Aliases: A830049P17Rik; KIAA0883; MA2; mKIAA0883; MM2; PNMA2; RGAG2
UniProt ID: (Human) Q9UL42, (Mouse) Q8BHK0
Entrez Gene ID: (Human) 10687, (Mouse) 239157, (Rat) 305977
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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