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Invitrogen
PNP Polyclonal Antibody
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Product Details
PA5-51616
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PNP. Recombinant protein control fragment (Product #RP-98841).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645720
Product Specific Information
Immunogen sequence: YTYEDYKNTA EWLLSHTKHR PQVAIICGSG LGGLTDKLTQ AQIFDYGEIP NFPRSTVPGH AGRLVFGFLN GRACVMMQGR FHMYEGYPLW KVTFPVRVFH LLGVDTLVVT NAAGGLNPKF EVGDIMLIRD HINLPGFSGQ NPLRGPNDER GAPHR
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 87%.
Target Information
This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 156an; HEL-S-156an; Inosine phosphorylase; inosine phosphorylase {ECO:0000250|UniProtKB:P00491}; Inosine-guanosine phosphorylase; nucleoside phosphorylase; PNP; PNP {ECO:0000250|UniProtKB:P00491}; Purine nucleoside phosphorylase; purine nucleoside phosphorylase {ECO:0000250|UniProtKB:P00491}; purine-nucleoside phosphorylase 1; purine-nucleoside:orthophosphate ribosyltransferase
Gene Aliases: AL024301; AU015798; NP; Np-1; Np-2; PNP; Pnp1; PRO1837; PUNP
UniProt ID: (Human) P00491, (Mouse) P23492
Entrez Gene ID: (Human) 4860, (Mouse) 18950, (Rat) 290029
nucleobase-containing compound metabolic process
inosine catabolic process
purine nucleotide catabolic process
nicotinamide riboside catabolic process
immune response
NAD biosynthesis via nicotinamide riboside salvage pathway
urate biosynthetic process
positive regulation of T cell proliferation
response to drug
purine-containing compound salvage
positive regulation of alpha-beta T cell differentiation
interleukin-2 secretion
positive regulation of T cell mediated cytotoxicity
deoxyinosine catabolic process
deoxyguanosine catabolic process
GTP biosynthetic process
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
nucleoside metabolic process
response to gamma radiation
purine nucleoside metabolic process
positive regulation of B cell differentiation
positive regulation of DNA repair
dGTP metabolic process
guanosine catabolic process
negative regulation of T cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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