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Product Details
CL59414929100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GDP-fucose protein O-fucosyltransferase 1; o-fucosyltransferase protein; O-FucT-1; Peptide-O-fucosyltransferase 1; pofut1 {ECO:0000312|RGD:1303001}
Gene Aliases: DDD2; FUT12; KIAA0180; mKIAA0180; O-Fuc-T; O-FucT-1; O-FUT; OFUCT1; POFUT1
UniProt ID: (Human) Q9H488, (Mouse) Q91ZW2, (Rat) Q6EV70
Entrez Gene ID: (Human) 23509, (Mouse) 140484, (Rat) 311551
angiogenesis
somitogenesis
fucose metabolic process
regulation of transcription, DNA-templated
protein O-linked glycosylation
Notch signaling pathway
nervous system development
heart development
embryo development
O-glycan processing
protein O-linked fucosylation
carbohydrate metabolic process
fucosylation
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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