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POM121 Antibody (PA5-85161) in ICC/IF
Immunocytochemistry (Confocal immunofluorescence) of POM121 in methanol-fixed HeLa. Samples were incubated with POM121 polyclonal antibody (Product # PA5-85161) using a dilution of 1:500 (green). Alpha-tubulin filaments were labeled with alpha Tubulin monoclonal antibody (Product # MA1-25054) (red) at 1:500.
Product Details
PA5-85161
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human POM121. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792308
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (82%), Rat (81%).
Positive Control: A549.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121) or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spiced isoforms and belongs to the POM121 family. Encoded by a gene that maps to human chromosome 7q11.23, POM121 is highly conserved and localizes to nucleus membrane and endoplasmic reticulum membrane. An essential component of the nuclear pore complex (NPC), POM121 is mandatory for nuclear envelope formation and may play a role in biogenesis of the NPC. POM121 associates with the central spoke ring complex and is involved in anchoring components of the pore complex to the pore membrane by way of its F-X-F-G repeat-containing domain. POM121 overexpression induces the formation of cytoplasmic annulate lamellae (AL).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear envelope pore membrane protein POM 121; Nuclear envelope pore membrane protein POM 121A; nuclear pore membrane protein 121 kDa; nuclear pore membrane protein 121-2; Nucleoporin Nup121; POM121 membrane glycoprotein; POM121 membrane glycoprotein C; POM121B; Pore membrane protein of 121 kDa; pore membrane protein of 121 kDa C
Gene Aliases: 2610027A18Rik; C80273; KIAA0618; mKIAA0618; NUP121; P145; POM121; POM121-2; POM121A
UniProt ID: (Human) Q96HA1, (Mouse) Q8K3Z9
Entrez Gene ID: (Human) 9883, (Human) 100101267, (Mouse) 107939
RNA export from nucleus
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
intracellular transport of virus
regulation of cellular response to heat
transport
nuclear pore organization
protein transport
mRNA transport
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