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Proteintech
PON1 Polyclonal Antibody
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Product Details
18155-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PON1 Fusion Protein Ag12934 (1-355 aa encoded by BC074719)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Glycosylated PON1 migrates at 42-45 kDa. 55 kDa is a dimmer of isoform CRA-b. The antibody has cross-reaction to PON2 and PON3.
Immunogen sequence: MAKLIALTL LGMGLALFRN HQSSYQTRLN ALREVQPVEL PNCNLVKGIE TGSEDLEILP NGLAFISSGL KYPGIKSFNP NSPGKILLMD LNEEDPTVLE LGITGSKFDV SSFNPHGIST FTDEDNAMYL LVVNHPDAKS TVELFKFQEE EKSLLHLKTI RHKLLPNLND IVAVGPEHFY GTNDHYFLDP YLQSWEMYLG LAWSYVVYYS PSEVRVVAEG FDFANGINIS PDGKYVYIAE LLAHKIHVYE KHANWTLTPL KSLDFNTLVD NISVDPETGD LWVGCHPNGM KIFFYDSENP PASEVLRIQN ILTEEPKVTQ VYAENGTVLQ GSTVASVYKG KLLIGTVFHK ALYCEL (1-355 aa encoded by B C074719)
Target Information
The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A esterase 1; A-esterase 1; Aromatic esterase 1; arylesterase 1; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESAesterase A; esterase A; K-45; paraoxonase B-type; PON 1; serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; Serum paraoxonase/arylesterase 1
Gene Aliases: ESA; MVCD5; PON; PON1
UniProt ID: (Human) P27169, (Mouse) P52430, (Rat) P55159
Entrez Gene ID: (Human) 5444, (Mouse) 18979, (Rat) 84024
blood circulation
cholesterol metabolic process
response to toxic substance
positive regulation of cholesterol efflux
dephosphorylation
aromatic compound catabolic process
positive regulation of transporter activity
carboxylic acid catabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
response to fluoride
lipid metabolic process
response to nutrient levels
negative regulation of plasma lipoprotein particle oxidation
response to fatty acid
response to external stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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