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Invitrogen
POT1 Polyclonal Antibody
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Product Details
PA1-16830
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide made to an internal portion of the human POT1 protein sequence (between residues 200-300).
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2166765
Product Specific Information
The target sequence has 95% sequence homology with monkey, 82% sequence homology with rat, and 72% sequence homology with mouse.
Suggested positive control: HeLa nuclear extract, antigen standard for POT1 (transient overexpression lysate).
Target Information
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586D211; hPot1; POT 1; POT-1; POT1-like telomere end-binding protein; protection of telomeres 1 homolog; Protection of telomeres protein 1
Gene Aliases: CMM10; GLM9; HPOT1; POT1
UniProt ID: (Human) Q9NUX5
Entrez Gene ID: (Human) 25913
telomere maintenance via telomerase
telomere capping
telomere assembly
positive regulation of telomere maintenance via telomerase
DNA duplex unwinding
positive regulation of helicase activity
positive regulation of telomerase activity
negative regulation of telomerase activity
positive regulation of DNA strand elongation
establishment of protein localization to telomere
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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