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Invitrogen
PP1 alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (HL1677)
FIGURE: 1 / 2
PP1 alpha/beta/gamma Antibody (MA5-47138) in WB
Western blot analysis of PP1 alpha/beta/gamma in Various whole cell extracts (30 µg) separated by 10% SDS-PAGE. Membrane was blotted with PP1 alpha/beta/gamma Monoclonal antibody (Product # MA5-47138) using a dilution of 1:1,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody.
Product Details
MA5-47138
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
HL1677
Immunogen
Recombinant fragment of human PP1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2938210
Product Specific Information
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
Target Information
PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription|Increased PP1 activity has been observed in the end stage of heart failure|Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer|PP1 alpha is one of the three catalytic subunits of protein phosphatase 1 (PP1)|This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity|PP1 beta encodes the beta isozyme and PP1 gamma encodes the gamma isozyme
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; HEL-S-80p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; NSLH2; p45; PP-1A; PP-1B; PP-1G; PP1A; PP1alpha; PP1B; PP1beta; PP1C; PPP1A; PPP1CD; PPP1G; protein phosphatase 1 catalytic subunit alpha; protein phosphatase 1 catalytic subunit beta; protein phosphatase 1 catalytic subunit gamma
Gene Aliases: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975
UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752
Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011
endopeptidase activity
cysteine-type endopeptidase activity
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
cysteine-type endopeptidase activity involved in apoptotic process
protein kinase activity
protein serine/threonine kinase activity
ATP binding
kinase activity
response to hypoxia
proteolysis
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
regulation of autophagy
protein processing
response to lipopolysaccharide
interleukin-1 beta production
response to ATP
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
regulation of inflammatory response
mitochondrial depolarization
membrane hyperpolarization
pyroptosis
cellular response to mechanical stimulus
cellular response to organic substance
programmed necrotic cell death
toxin transport
cell morphogenesis
phagocytosis
regulation of cell shape
Wnt signaling pathway
peptidyl-serine phosphorylation
protein phosphorylation
Golgi organization
mitotic nuclear division
cell surface receptor signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
intermediate filament cytoskeleton organization
cell division
negative regulation of canonical Wnt signaling pathway
regulation of GTP binding
beta-catenin destruction complex assembly
beta-catenin destruction complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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