Invitrogen

PPARGC1A Polyclonal Antibody

View all (2) PPARGC1A antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-144904

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 300-381.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3092037

Product Specific Information

Immunogen sequence: PPHKANQDNP FRASPKLKSS CKTVVPPPSK KPRYSESSGT QGNNSTKKGP EQSELYAQLS KSSVLTGGHE ERKTKRPSLR LF

Antigen sequence identity: Mouse 87%; Rat 88%

Target Information

PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; pgc-1 alpha; PGC-1-alpha; PPAR gamma coactivator variant form; PPARgamma coactivator 1alpha; PPARGC-1-alpha

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Gene Aliases: LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1; PPARGC1A

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UniProt ID: (Human) Q9UBK2

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Entrez Gene ID: (Human) 10891

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Function(s)
nucleotide binding RNA polymerase II transcription cofactor activity DNA binding transcription coactivator activity RNA binding protein binding transcription factor binding ligand-dependent nuclear receptor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity chromatin DNA binding ubiquitin protein ligase binding peroxisome proliferator activated receptor binding alpha-tubulin binding sequence-specific DNA binding androgen receptor binding promoter-specific chromatin binding
Process(es)
response to reactive oxygen species mitophagy temperature homeostasis cellular glucose homeostasis negative regulation of protein phosphorylation response to dietary excess response to ischemia galactose metabolic process gluconeogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter mRNA processing protein complex assembly mitochondrion organization positive regulation of transcription from RNA polymerase II promoter by pheromones aging digestion circadian rhythm androgen metabolic process RNA splicing response to cold positive regulation of mitochondrion organization skeletal muscle atrophy response to muscle activity response to electrical stimulus involved in regulation of muscle adaptation negative regulation of smooth muscle cell migration fatty acid oxidation cerebellum development respiratory electron transport chain androgen receptor signaling pathway forebrain development circadian regulation of gene expression cellular response to oxidative stress positive regulation of histone acetylation cellular response to potassium ion response to statin response to drug response to starvation regulation of circadian rhythm response to leucine negative regulation of neuron apoptotic process cellular respiration positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation protein stabilization brown fat cell differentiation positive regulation of sequence-specific DNA binding transcription factor activity flavone metabolic process adipose tissue development cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to follicle-stimulating hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus response to epinephrine response to norepinephrine negative regulation of mitochondrial fission cellular response to thyroid hormone stimulus negative regulation of neuron death response to metformin positive regulation of cellular respiration positive regulation of mitochondrial DNA metabolic process positive regulation of muscle tissue development positive regulation of glomerular visceral epithelial cell apoptotic process cellular response to ionomycin cellular response to resveratrol response to methionine adaptive thermogenesis positive regulation of progesterone biosynthetic process negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of energy homeostasis positive regulation of ATP biosynthetic process
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