Proteintech

PPARGC1B Polyclonal Antibody

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PPARGC1B Antibody (22378-1-AP) in WB

Mouse liver tissue were subjected to SDS PAGE followed by western blot with 22378-1-AP ( PPARGC1B Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

PPARGC1B Antibody in Immunoprecipitation (IP)

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Product Details

22378-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 13 publications 13 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Fish, Goat, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PPARGC1B Fusion Protein Ag17566 (1-350 aa encoded by BC132971)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAGNDCGAL LDEELSSFFL NYLADTQGGG SGEEQLYADF PELDLSQLDA SDFDSATCFG ELQWCPENSE TEPNQYSPDD SELFQIDSEN EALLAELTKT LDDIPEDDVG LAAFPALDGG DALSCTSASP APSSAPPSPA PEKPSAPAPE VDELSLLQKL LLATSYPTSS SDTQKEGTAW RQAGLRSKSQ RPCVKADSTQ DKKAPMMQSQ SRSCTELHKH LTSAQCCLQD RGLQPPCLQS PRLPAKEDKE PGEDCPSPQP APASPRDSLA LGRADPGAPV SQEDMQAMVQ LIRYMHTYCL PQRKLPPQTP EPLPKACSNP SQQVRSRPWS RHHSKASWAE FSILRELLAQ D (1-350 aa encoded by BC132971)

Target Information

PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Cancer research

Zhao M,Li Y,Lu C,Ding F,Xu M,Ge X,Li M,Wang Z,Yin J,Zhang J,Wang X,Ge Z,Xiao H,Xiao Y,Liu H,Liu W,Cao Y,Wang Q,You Y,Wang X,Yang K,Shi Z,Qian X

Tue Apr 04 00:00:00 UTC 2023

miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation.

Redox biology

Wang X,Yang J,Li H,Mu H,Zeng L,Cai S,Su P,Li H,Zhang L,Xiang W

Thu Jun 01 00:00:00 UTC 2023

Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Tang M,Xu H,Huang H,Kuang H,Wang C,Li Q,Zhang X,Ge Y,Song M,Zhang X,Wang Z,Ma C,Kang J,Zhang W,Wang Y,Zhang B,Zhang X,Chen Y,Cong M,Melino G,Wang X,Zhou F,Sun Q,Shi H

Sat Oct 01 00:00:00 UTC 2022

PGC-1β modulates catabolism and fiber atrophy in the fasting-response of specific skeletal muscle beds.

Molecular metabolism

Schmid S,Heim-Kupr B,Pérez-Schindler J,Mansingh S,Beer M,Mittal N,Ehrenfeuchter N,Handschin C

Thu Dec 01 00:00:00 UTC 2022

Interactions between dietary carbohydrate and thiamine: implications on the growth performance and intestinal mitochondrial biogenesis and function of Megalobrama amblycephala.

The British journal of nutrition

Xu C,Li YY,Brown PB,Liu WB,Gao LL,Ding ZR,Li XF,Xie DZ

Mon Feb 14 00:00:00 UTC 2022

Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine.

Cell reports

Han L,Wang G,Zhou S,Situ C,He Z,Li Y,Qiu Y,Huang Y,Xu A,Ong MTY,Wang H,Zhang J,Wu Z

Tue May 31 00:00:00 UTC 2022

Andrographolide prevents bone loss via targeting estrogen-related receptor-α-regulated metabolic adaption of osteoclastogenesis.

British journal of pharmacology

Huang T,Fu X,Wang N,Yang M,Zhang M,Wang B,Chen T,Majaz S,Wang H,Wong CW,Liu J,Guan M

Mon Nov 01 00:00:00 UTC 2021

Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis.

EMBO reports

Liu L,Li Y,Wang J,Zhang D,Wu H,Li W,Wei H,Ta N,Fan Y,Liu Y,Wang X,Wang J,Pan X,Liao X,Zhu Y,Chen Q

Wed Mar 03 00:00:00 UTC 2021

Carbonyl cyanide 3-chlorophenylhydrazone induced the imbalance of mitochondrial homeostasis in the liver of Megalobrama amblycephala: A dynamic study.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

Zhang L,Zheng XC,Huang YY,Ge YP,Sun M,Chen WL,Liu WB,Li XF

Tue Jun 01 00:00:00 UTC 2021

Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer.

The FEBS journal

Gao Y,Yang F,Yang XA,Zhang L,Yu H,Cheng X,Xu S,Pan J,Wang K,Li P

Mon Apr 01 00:00:00 UTC 2019

miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta.

Journal of animal science and biotechnology

Ma L,Qiu H,Chen Z,Li L,Zeng Y,Luo J,Gou D

Fri Mar 18 00:00:00 UTC 2022

miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta.

Journal of animal science and biotechnology

Ma L,Qiu H,Chen Z,Li L,Zeng Y,Luo J,Gou D

Fri Mar 18 00:00:00 UTC 2022

Benfotiamine, a Lipid-Soluble Analog of Vitamin B₁, Improves the Mitochondrial Biogenesis and Function in Blunt Snout Bream (Megalobrama amblycephala) Fed High-Carbohydrate Diets by Promoting the AMPK/PGC-1β/NRF-1 Axis.

Frontiers in physiology

Xu C,Liu WB,Zhang DD,Shi HJ,Zhang L,Li XF

Thu Sep 28 00:00:00 UTC 2023

Frontiers in physiology

Xu C,Liu WB,Zhang DD,Shi HJ,Zhang L,Li XF

Thu Sep 28 00:00:00 UTC 2023

Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p/PGC-1β axis in high-fat diet-induced hyperlipidemic mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chen S,Wen X,Zhang W,Wang C,Liu J,Liu C

Wed Mar 01 00:00:00 UTC 2017

Hypolipidemic effect of oleanolic acid is mediated by the miR-98-5p/PGC-1β axis in high-fat diet-induced hyperlipidemic mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chen S,Wen X,Zhang W,Wang C,Liu J,Liu C

Wed Mar 01 00:00:00 UTC 2017

Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets.

The British journal of nutrition

Fan Q,Long B,Yan G,Wang Z,Shi M,Bao X,Hu J,Li X,Chen C,Zheng Z,Yan X

Mon May 01 00:00:00 UTC 2017

Dietary leucine supplementation alters energy metabolism and induces slow-to-fast transitions in longissimus dorsi muscle of weanling piglets.

The British journal of nutrition

Fan Q,Long B,Yan G,Wang Z,Shi M,Bao X,Hu J,Li X,Chen C,Zheng Z,Yan X

Mon May 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: ERR ligand 1; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-beta; PPARgamma coactivator 1 beta; PPARGC-1-beta

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Gene Aliases: 4631412G21Rik; ERRL1; PERC; PGC-1(beta); PGC1; PGC1B; PPARGC1; PPARGC1B

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UniProt ID: (Human) Q86YN6, (Mouse) Q8VHJ7

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Entrez Gene ID: (Human) 133522, (Mouse) 170826

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Function(s)

nucleotide binding RNA polymerase II transcription cofactor activity RNA binding transcription factor binding estrogen receptor binding ligand-dependent nuclear receptor transcription coactivator activity receptor activator activity AF-2 domain binding nucleic acid binding protein binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PPARGC1B Polyclonal Antibody

PPARGC1B Antibody (22378-1-AP) in WB

Product Details

22378-1-AP

Western Blot (WB)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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