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Invitrogen
PPM1A Polyclonal Antibody
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Product Details
PA5-83075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PPM1A. Recombinant protein control fragment (Product #RP-98836).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2790231
Product Specific Information
Immunogen sequence: GQGNGLRYGL SSMQGWRVEM EDAHTAVIGL PSGLESWSFF AVYDGHAGSQ VAKYCCEHLL DHITNNQDFK GSAGAPSVEN VKNGIRTGFL EIDEHMRVMS EKKHGADRSG STAVGVLISP QHTYFINCGD SRGLLCRNRK VHFFTQDHKP SGAPHR
Target Information
PPM1A (Protein phosphatase 1A) is also named as PPPM1A and belongs to the PP2C family. It is a serine/threonine protein phosphatase that is essential for regulating cellular stress responses in eukaryotes. PPM1A plays an important role in tumor suppression and that it negatively controls many signaling pathways which are critical for trophoblast invasion. This protein distributes in both the cytoplasm and nucleus of mammalian cells. It has 2 isoforms produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PP2C-alpha; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Aliases: PP2C-ALPHA; PP2CA; PP2Calpha; PPM1A; PPPM1A
UniProt ID: (Human) P35813
Entrez Gene ID: (Human) 5494
negative regulation of transcription from RNA polymerase II promoter
protein dephosphorylation
N-terminal protein myristoylation
cell cycle arrest
negative regulation of SMAD protein complex assembly
Wnt signaling pathway
dephosphorylation
positive regulation of Wnt signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
peptidyl-threonine dephosphorylation
negative regulation of NF-kappaB import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription, DNA-templated
positive regulation of protein export from nucleus
cellular response to transforming growth factor beta stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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