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Abnova
PPP1R9A Monoclonal Antibody (6A10)
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Product Details
H00055607-M01
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
6A10
Immunogen
PPP1R9A (XP_371933, 1090 a.a. approximately 1188 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PCSTAQTSTR SPCMPFSWFN DSRKGSYSFR NLPAPTSSLQ PSPETLISDK KGSKNFTFND DFSPSSTSSA DLSGLGAEPK TPGLSQSLAL SSDESLDMI
Target Information
Neurabin I is a brain-specific protein which contains an F-actin binding domain, a PDZ domain, a transmembrane-protein-interacting-domain, and a coiled-coil region. As its structure suggests, neurabin I is a promiscuous protein binding to F-actin, protein phosphatase 1, TGN38, and p70 S6 kinase. Found exclusively in brain, this protein is highly concentrated in the synapse and has also been shown to be enriched in the lamellipodia of the growth cone during neuronal development. Neurabin I appears to be a bridging protein by targeting other proteins to the synapse or by linking membrane proteins to the actin cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin-binding protein neurabin; neurabin 1; Neurabin-1; Neurabin-I; Neural tissue-specific F-actin-binding protein I; p180; PP1bp175; Protein phosphatase 1 regulatory subunit 9A; protein phosphatase 1, regulatory (inhibitor) subunit 9A; protein phosphatase 1, regulatory subunit 9A
Gene Aliases: KIAA1222; Neb1; Neurabin-I; NRB1; NRBI; PPP1R9A
UniProt ID: (Human) Q9ULJ8, (Rat) O35867
Entrez Gene ID: (Human) 55607, (Rat) 84685
actin filament organization
aging
calcium-mediated signaling
regulation of actin filament polymerization
neuron projection development
positive regulation of protein kinase activity
regulation of filopodium assembly
negative regulation of stress fiber assembly
regulation of synapse structural plasticity
regulation of synapse assembly
excitatory postsynaptic potential
positive regulation of dendritic spine development
regulation of dendritic spine morphogenesis
cellular response to toxic substance
negative regulation of long-term synaptic potentiation
positive regulation of long term synaptic depression
negative regulation of spontaneous neurotransmitter secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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