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Proteintech
PPP2R2B Polyclonal Antibody
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Product Details
13123-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPP2R2B Fusion Protein Ag3860 (100-443 aa encoded by BC031790)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QQNAAYFLL STNDKTVKLW KVSERDKRPE GYNLKDEEGR LRDPATITTL RVPVLRPMDL MVEATPRRVF ANAHTYHINS ISVNSDYETY MSADDLRINL WNFEITNQSF NIVDIKPANM EELTEVITAA EFHPHHCNTF VYSSSKGTIR LCDMRASALC DRHTKFFEEP EDPSNRSFFS EIISSISDVK FSHSGRYIMT RDYLTVKVWD LNMENRPIET YQVHDYLRSK LCSLYENDCI FDKFECVWNG SDSVIMTGSY NNFFRMFDRN TKRDVTLEAS RENSKPRAIL KPRKVCVGGK RRKDEISVDS LDFSKKILHT AWHPSENIIA VAATNNLYIF QDKVN (100-443 aa encoded by BC031790)
Target Information
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BRbeta B-regulatory subunit of protein phosphatase 2A; PP2A PP2ABBETA; PP2A subunit B isoform B55-beta; PP2A subunit B isoform beta; PP2A subunit B isoform BRB; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform R2-beta; PP2A, subunit B, B-beta isoform; PP2A, subunit B, B55-beta isoform; PP2A, subunit B, BRB isoform; PP2A, subunit B, PR55-beta isoform; PP2A, subunit B, R2-beta isoform; PR2A PR2ABBETA; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform; protein phosphatase 2 regulatory subunit B, beta; protein phosphatase 2, regulatory subunit B, beta; serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform; serine/threonine protein phosphatase 2A, neuronal isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Gene Aliases: 2900026H06Rik; 6330404L05Rik; B55BETA; E130009M08Rik; PP2A-PR55B; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2APR55BETA; PPP2R2B; Pppr2b2; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52B; PR55-BETA; PR55BETA; SCA12
UniProt ID: (Human) Q00005, (Rat) P36877, (Mouse) Q6ZWR4
Entrez Gene ID: (Human) 5521, (Rat) 60660, (Mouse) 72930
apoptotic process
regulation of protein phosphatase type 2A activity
mitochondrial fission
protein targeting to mitochondrion
signal transduction
spermatid development
brain development
neuron differentiation
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
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