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Proteintech
PPP3R1 Polyclonal Antibody
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Product Details
13210-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PPP3R1 Fusion Protein Ag3992 (1-170 aa encoded by BC027913)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGNEASYPL EMCSHFDADE IKRLGKRFKK LDLDNSGSLS VEEFMSLPEL QQNPLVQRVI DIFDTDGNGE VDFKEFIEGV SQFSVKGDKE QKLRFAFRIY DMDKDGYISN GELFQVLKMM VGNNLKDTQL QQIVDKTIIN ADKDGDGRIS FEEFCAVVGG LDIHKKMVVD V (1-170 aa encoded by BC027913)
Target Information
Calcineurin is a Ser/Thr, calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin (also referred to as protein phosphatase 2B) is composed of two subunits; calcineurin A (CnA), a 60 kDa catalytic subunit which is highly homologous to protein phosphatases 1 and 2A; and a 19 kDa regulatory subunit, calcineurin B (CnB) which, like calmodulin, contains four EF-hand calcium binding sites. Calcineurin-mediated dephosphorylation of the nuclear factor of activated T-cells (NF-AT) is essential for NF-AT activation, nuclear translocation, and early gene expression in T-cells. The immunosuppressive drugs, cyclosporin A and FK506, when bound to the immunophilins, cyclophilin and FKBP respectively, inhibit dephosphorylation and activation of NF-AT by calcineurin. This inhibition is caused by the immunosuppressant/immunophilin complex simultaneously binding to both CnA and CnB which does not inhibit the phosphatase activity of CnA, but rather blocks access of the substrate to the catalytic domain of CnA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ALNB1; calcineurin B, type I (19kDa); Calcineurin subunit B type 1; Protein phosphatase 2B regulatory subunit 1; protein phosphatase 2B regulatory subunit B alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I); protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 3 regulatory subunit B alpha isoform 1; protein phosphatase 3, regulatory subunit B, alpha
Gene Aliases: CALNB1; CNA2; CNB; CNB1; PPP3R1
UniProt ID: (Human) P63098
Entrez Gene ID: (Human) 5534
protein dephosphorylation
Wnt signaling pathway, calcium modulating pathway
calcineurin-NFAT signaling cascade
Fc-epsilon receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NFAT protein import into nucleus
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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