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Bethyl Laboratories
PPP6C Polyclonal Antibody
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FIGURE: 1 / 3
PPP6C Antibody (A300-844A) in WB
Detection of human PPP6C by western blot. Samples: Whole cell lysate (25 µg) from HEK293T, Jurkat, U2OS, GaMG, and MCF-7 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-PPP6C antibody (Product # A300-844A lot 2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A300-844A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 250 and the C-terminus (residue 305) of Human Protein Phosphatase 6, Catalytic Subunit.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat
Target Information
Distinct DNA repair pathways minimize the consequences of mutagenic events. Reactive oxygen species (ROS) are highly reactive atoms with an unpaired electron that are conducive to double-strand DNA breaking events. Artemis, named after the Greek goddess for the protection of children, is one of the major proteins contributing to the preservation of double-strand breaks in DNA by cutting away the damaged parts of the DNA, which allows the strands to rejoin. Artemis is a single-strand-specific 5' to 3' exonuclease that forms a complex with the 469 kDa DNA-dependent protein kinase (DNA-PKcs). DNA-PKcs phosphorylates Artemis, and Artemis acquires endonucleolytic activity on 5' and 3' overhangs and hairpins. These activities are essential for V(D)J recombination and for the 5' and 3' overhang processing in nonhomologous DNA end joining.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANKRD33; FLJ34236; PP6C; protein phosphatase 6, catalytic subunit; serine/threonine protein phosphatase catalytic subunit; Serine/threonine-protein phosphatase 6 catalytic subunit; UNQ5837
Gene Aliases: 2310003C10Rik; PP6; PP6C; PPP6; PPP6C
UniProt ID: (Human) O00743, (Mouse) Q9CQR6
Entrez Gene ID: (Human) 5537, (Mouse) 67857
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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