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Invitrogen
PR3 Monoclonal Antibody (3B4)
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Product Details
MA5-15540
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
3B4
Immunogen
Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982680
Product Specific Information
MA5-15540 targets Proteinase 3 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15540 immunogen is purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
MA5-15540 detects Proteinase 3 which has a predicted molecular weight of approximately 28kDa.
Target Information
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGP7; azurophil granule protein 7; C-ANCA antigen; Leukocyte proteinase 3; Myeloblastin; Neutrophil proteinase 4; NP-4; P29; PR-3; serine proteinase, neutrophil; Wegener autoantigen; Wegener granulomatosis autoantigen
Gene Aliases: ACPA; AGP7; C-ANCA; CANCA; MBN; MBT; NP-4; NP4; P29; PR-3; PR3; PRTN3
UniProt ID: (Human) P24158
Entrez Gene ID: (Human) 5657
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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