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Proteintech
PRAME Polyclonal Antibody
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Product Details
11438-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PRAME Fusion Protein Ag1906 (1-509 aa encoded by BC014074)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERRRLWGS IQSRYISMSV WTSPRRLVEL AGQSLLKDEA LAIAALELLP RELFPPLFMA AFDGRHSQTL KAMVQAWPFT CLPLGVLMKG QHLHLETFKA VLDGLDVLLA QEVRPRRWKL QVLDLRKNSH QDFWTVWSGN RASLYSFPEP EAAQPMTKKR KVDGLSTEAE QPFIPVEVLV DLFLKEGACD ELFSYLIEKV KRKKNVLRLC CKKLKIFAMP MQDIKMILKM VQLDSIEDLE VTCTWKLPTL AKFSPYLGQM INLRRLLLSH IHASSYISPE KEEQYIAQFT SQFLSLQCLQ ALYVDSLFFL RGRLDQLLRH VMNPLETLSI TNCRLSEGDV MHLSQSPSVS QLSVLSLSGV MLTDVSPEPL QALLERASAT LQDLVFDECG ITDDQLLALL PSLSHCSQLT TLSFYGNSIS ISALQSLLQH LIGLSNLTHV LYPVPLESYE DIHGTLHLER LAYLHARLRE LLCELGRPSM VWLSANPCPH CGDRTFYDPE PILCPCFMPN (1-509 aa encoded by BC014074)
Target Information
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer/testis antigen 130; Melanoma antigen preferentially expressed in tumors; OIP-4; Opa-interacting protein 4; Opa-interacting protein OIP4; Preferentially expressed antigen of melanoma
Gene Aliases: CT130; MAPE; OIP-4; OIP4; PRAME
UniProt ID: (Human) P78395
Entrez Gene ID: (Human) 23532
transcription, DNA-templated
apoptotic process
positive regulation of cell proliferation
cell differentiation
regulation of growth
negative regulation of apoptotic process
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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