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Invitrogen
PRAME Polyclonal Antibody
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PRAME Antibody (PA5-83761)
Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of PRAME was observed specifically in U2OS cells and in SK-MEL-30 cells using anti-PRAME Polyclonal Antibody (Product #PA5-83761) in western blot. The relative expression levels of PRAME within each cell line is shown using RNA-Seq... View More
Product Details
PA5-83761
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRAME. Recombinant protein control fragment (Product #RP-88805).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2790913
Product Specific Information
Immunogen sequence: LLLSHIHASS YISPEKEEQY IAQFTSQFLS LQCLQALYVD SLFFLRGRLD QLLRHVMNPL ETLSITNCRL SEGDVMHLSQ SPSVSQLSVL SLSGVMLTDV SPEPLQALLE RASATLQDLV FDECGI
Target Information
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cancer/testis antigen 130; Melanoma antigen preferentially expressed in tumors; OIP-4; Opa-interacting protein 4; Opa-interacting protein OIP4; Preferentially expressed antigen of melanoma
Gene Aliases: CT130; MAPE; OIP-4; OIP4; PRAME
UniProt ID: (Human) P78395
Entrez Gene ID: (Human) 23532
transcription, DNA-templated
apoptotic process
positive regulation of cell proliferation
cell differentiation
regulation of growth
negative regulation of apoptotic process
negative regulation of cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of retinoic acid receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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