Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
MA5-11144
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
33AT1045
Immunogen
Purified recombinant GST fusion protein encoding aa 1-347 of human RIZ1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2170140
Product Specific Information
This antibody is specific for RIZ1, it does not recognize the isoform beta (RIZ2).
Target Information
PRDM2, a member of nuclear/histone methyltransferase superfamily, consists of an N-terminal PR domain, an Rb-binding motif, 8 Kruppel-like zinc finger motifs, Nuclear hormone-receptor binding motif and a C-terminal PR-domain binding motif. Ubiquitously expressed in low levels, PRDM2 exists in 2 isoforms, a 280 kDa RIZ1 containing PR-domain and a 250 kDa truncated RIZ2 that lacks PR-domain. A tumor suppressor with a prominent role in cell growth and differentiation, PRDM2 binds to Retinoblastoma protein, estrogen receptor, GATA-3 and TPA-responsive element (MTE) of Heme-oxygenase-1 gene and influences pathogenesis of Retinoblastoma, transcriptional regulation during neuronal differentiation, transactivation of Heme-oxygenase-1 gene and specific effector of estrogen action. It is inactivated or altered due to mutations and hypermethylation in many types of human cancers suggesting a potential biomarker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: G3b; GATA-3 binding protein G3B; GATA-3-binding protein G3B; Lysine N-methyltransferase 8; MTB-ZF; MTBzf; MTE-binding protein; PR domain containing 2, with ZNF domain; PR domain zinc finger protein 2; PR domain-containing protein 2; retinoblastoma protein-binding zinc finger protein; Retinoblastoma protein-interacting zinc finger protein; RP5-1177E19.1; Zinc finger protein RIZ; zinc-finger DNA-binding protein
Gene Aliases: 4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; HUMHOXY1; KMT8; MTB-ZF; PRDM2; RIZ; RIZ1; RIZ2; Znfpr1c1
UniProt ID: (Human) Q13029
Entrez Gene ID: (Human) 7799, (Mouse) 110593
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support