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Invitrogen
PREB Polyclonal Antibody
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Product Details
PA5-40828
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human PREB (aa 140-189).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2577171
Product Specific Information
Peptide sequence: RVENLQAVQT DFSSDPLQKV VCFNHDNTLL ATGGTDGYVR VWKVPSLEKV
Sequence homology: Cow: 83%; Dog: 92%; Guinea Pig: 91%; Horse: 100%; Human: 100%; Mouse: 83%; Pig: 100%; Rabbit: 100%; Rat: 100%
Target Information
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary specific transcription factor that plays an important role in PRL expression, both in mature organism and during development. The PRL promoter contains numerous Pit-1 binding sites and these sites have been implicated in both basal level and kinase-mediated gene expression. The most proximal of these binding sites, termed 1P, has been shown to direct a response to numerous signals, such as cAMP and various G-proteins. A novel protein, termed PREB (prolactin regulatory element binding protein), has been recently identified that regulates PRL gene expression through the 1P site, though it contains no discernable DNA-binding motif. Recent studies suggest that PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB is a novel transcription factor that assists in PRL expression whether alone, or in concert with Pit-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Guanine nucleotide-exchange factor SEC12; mammalian guanine nucleotide exchange factor mSec12; prolactin regulatory binding-element protein; Prolactin regulatory element-binding protein
Gene Aliases: PREB; SEC12
UniProt ID: (Human) Q9HCU5
Entrez Gene ID: (Human) 10113
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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